Regulation of Myelination and Glucose Metabolism by Phosphoinositides of Myelination of Myelination and Glucose Metabolism by Phosphoinositides

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790055
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Akita University
• Principal Investigator: TAKASUGA Shunsuke 秋田大学, 大学院・医学系研究科, 助教 (90375262)
• Project Period (FY): 2010 – 2011
• Keywords: 脂質 / 脳神経疾患 / 糖尿病

Research Abstract

We made tissue-specific phosphatidylinositol 3-phosphate 5-kinase (PIPKIII) knockout mice for analyses of myelination in central nervous system and glucose metabolism in muscle. We indicated that essential roles of PIPKIII in oligodendrocytes. And we also found that PIPKIII is a negative regulator of insulin signaling in skeletal muscle.

Research Products

• [Journal Article] 3'phosphatase activity toward PI (3,4) P2 by voltage-sensing phosphatase, VSP. (2012)
  • Author(s): Kurokawa T, Takasuga S, Sakata S, Yamaguchi S, Horie S, Homma KJ, Sasaki T, Okamura Y
  • Journal Title: Proc Natl Acad Sci USA Volume: (in press)
• [Journal Article] Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages (2011)
  • Author(s): Hazeki K, Kametani Y, Murakami H, Uehara M, Ishikawa Y, Nigorikawa K, Takasuga S, Sasaki T, Seya T, Matsumoto M, Hazeki O
  • Journal Title: PLoS One Volume: 6 Pages: e26836
  • DOI: 10.1371/journal.pone.0026836
• [Journal Article] The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death (2010)
  • Author(s): Sasaki J, Kofuji S, Itoh R, Momiyama T, Takayama K, Murakami H, Chida S, Tsuya Y, Takasuga S, Eguchi S, Asanuma K, Horie Y, Miura K, Davies EM, Mitchell C, Yamazaki M, Hirai H, Takenawa T, Suzuki A, Sasaki T
  • Journal Title: Nature Volume: 465 Pages: 497-501
  • DOI: DOI:10.1038/nature09023
• [Journal Article] Novel acyl-coenzyme A : monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion (2010)
  • Author(s): Hiramine Y, Emoto H, Takasuga S, Hiramatsu R
  • Journal Title: J.Lipid Res Volume: 51 Pages: 1424-1431
  • DOI: DOI:10.1194/jlr.M002584
• [Presentation] Physiological function of phosphatidylinositol-3, 5-bisphosphate in vivo (2010)
  • Author(s): Takasuga S, Sasaki J, Suzuki A, Sasaki T
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-05-19