2011 Fiscal Year Final Research Report
Role of arachidonic acid cascade on neurodegeneration in Niemann-Pick desease type C.
| Project/Area Number |
22790056
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | アラキドン酸代謝 / ニーマンピック病C型 |
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| Research Abstract |
In this study, we investigated the metabolism of arachidonic acid in NPC. In addition, we examined the effect of sphingolipids accumulated in NPC on the metabolisms of arachidonic acid. We showed that 1) cPLA2α-dependent arachidonic acid metabolism plays important roles in the cytotoxicity and the ROS formation in NPC cells, 2) SM and LacCer are direct regulators of cPLA2α.
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Research Products
(29 results)
