2011 Fiscal Year Final Research Report
Mechanism of substrate selectivity of gamma-secretase regulated by membrane trafficking
| Project/Area Number |
22790061
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Research Collaborator |
IWATSUBO Takeshi 東京大学, 大学院・医学系研究科, 教授
TOMITA Taisuke 東京大学, 大学院・薬学系研究科, 准教授
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| Project Period (FY) |
2010 – 2011
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| Keywords | 細胞生物学 |
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| Research Abstract |
γ-Secretase is a membrane embedded protease responsible for the production of pathogenic Aβpeptide accumulated in the brains of AD patient, therefore it has been regarded as a promising druggable target for the treatment of AD.γ-Secretase has a number of substrates, so it is crucial to understand its molecular mechanism of substrate selectivety. To this end, we have identified Surf4 that specifically regulates Notch receptor trafficking. Surf4 recognizes the cytosolic portion of Notch receptor and recruits it to the ER-exit site, and regulate its ER-to-Golgi trafficking.
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