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2011 Fiscal Year Final Research Report

Mechanism of substrate selectivity of gamma-secretase regulated by membrane trafficking

Research Project

  • PDF
Project/Area Number 22790061
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionThe University of Tokyo

Principal Investigator

MOROHASHI Yuichi  東京大学, 大学院・薬学系研究科, 助教 (40568169)

Research Collaborator IWATSUBO Takeshi  東京大学, 大学院・医学系研究科, 教授
TOMITA Taisuke  東京大学, 大学院・薬学系研究科, 准教授
Project Period (FY) 2010 – 2011
Keywords細胞生物学
Research Abstract

γ-Secretase is a membrane embedded protease responsible for the production of pathogenic Aβpeptide accumulated in the brains of AD patient, therefore it has been regarded as a promising druggable target for the treatment of AD.γ-Secretase has a number of substrates, so it is crucial to understand its molecular mechanism of substrate selectivety. To this end, we have identified Surf4 that specifically regulates Notch receptor trafficking. Surf4 recognizes the cytosolic portion of Notch receptor and recruits it to the ER-exit site, and regulate its ER-to-Golgi trafficking.

  • Research Products

    (7 results)

All 2011 2010 Other

All Presentation (6 results) Remarks (1 results)

  • [Presentation] Identification and functional analysisof a genetic regulator forγ-secretasesubstrate trafficking2011

    • Author(s)
      一色隼,山下雄大,石渡智之,諸橋雄一,富田泰輔,岩坪威
    • Organizer
      第6回日本Notch研究会
    • Place of Presentation
      千葉
    • Year and Date
      20111114-15
  • [Presentation] Functional analysis of SFT-4 in the C. elegans Notch pathway2011

    • Author(s)
      石渡智之,一色隼人,桑原知樹,諸橋雄一,三谷昌平,富田泰輔,岩坪威
    • Organizer
      第6回日本Notch研究会
    • Place of Presentation
      千葉
    • Year and Date
      20111114-15
  • [Presentation] Identification and functional analysisof a genetic regulator forγ-secretasesubstrate trafficking2011

    • Author(s)
      一色隼人,山下雄大,石渡智之,諸橋雄一,富田泰輔,岩坪威
    • Organizer
      第30回日本認知症学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20111111-13
  • [Presentation] Functional analysis of SFT-4 in the C. elegans Notch pathway2011

    • Author(s)
      石渡智之,一色隼人,桑原知樹,諸橋雄一,三谷昌平,富田泰輔,岩坪威
    • Organizer
      第30回日本認知症学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20111111-13
  • [Presentation] Functional analysis of SFT-4 in the C. elegans Notch pathway2010

    • Author(s)
      石渡智之,一色隼人,桑原知樹,諸橋雄一,三谷昌平,富田泰輔,岩坪威
    • Organizer
      第5回Notch研究会
    • Place of Presentation
      千葉
    • Year and Date
      20101108-09
  • [Presentation] Functional analysis of SFT-4 in the C. elegans Notch pathway2010

    • Author(s)
      石渡智之,一色隼人,桑原知樹,諸橋雄一,三谷昌平,富田泰輔,岩坪威
    • Organizer
      4^<th> East Asia C. elegans Meeting
    • Place of Presentation
      東京
    • Year and Date
      20100711-14
  • [Remarks] 東京大学大学院薬学系研究科臨床薬学教室HP

    • URL

      http://web.f.u-tokyo.ac.jp/~neuropsc/entranceja.html

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Published: 2013-07-31  

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