2011 Fiscal Year Final Research Report
Mechanism of energy homeostasis maintenance via short-chain fatty acids receptor(GPR41), dietary energy sensor
| Project/Area Number |
22790065
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
KIMURA Ikuo 京都大学, 大学院・薬学研究科, 助教 (80433689)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 脂肪酸受容体 / 交感神経 / ノックアウトマウス / GPCR / 短鎖脂肪酸 |
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| Research Abstract |
Short-chain fatty acids(SCFAs) are the products of colonic bacterial degradation of unabsorbed dietary fiber, and have been suggested to modulate a various physiological responses including cardiovascular, metabolic and immune systems ; however, the underlying mechanism for the process is uncertain. Our present work clarified their regulatory mechanism of sympathetic nervous system in cardiovascular and metabolic systems. SCFAs and ketones, major energy sources in body, directly regulate sympathetic activity via GPR41. Examining the cardiac and metabolic sympathetic responses in mice lacking GPR41, we found that propionate and.-hydroxybutyrate(major SCFA and ketone body) promotes or depresses GPR41-mediated SNS activation, respectively. This novel regulatory mechanism of SNS by dietary fatty acids would be of importance not only in the physiology, but in the diseases.
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