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2011 Fiscal Year Final Research Report

The approach for therapy of food allergy to use mouse model

Research Project

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Project/Area Number 22790075
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionGifu Pharmaceutical University

Principal Investigator

YAMASHITA Hirotaka  岐阜薬科大学, 薬学部, 助教 (40453055)

Project Period (FY) 2010 – 2011
Keywords免疫学
Research Abstract

We developed novel food allergy model to use mice. In this model, mice were sensitized by ovalbumin and induced food allergy, such as hypothermia by anaphylactic shock and allergic diarrhea, by oral treatments of OVA. Then, we induced oral tolerance for food antigen by prior oral treatment with OVA.
We confirmed oral tolerance happened in the mice, which were not treated with OVA preliminarily, by transfer of mesenteric lymph node cells of oral tolerance-induced mice. Then I found that the transfer of tolerance was depended on Treg.

  • Research Products

    (5 results)

All 2012 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Overcoming food allergy through acquired tolerance conferred by transfer of Tregs in a murine model2012

    • Author(s)
      Hirotaka Yamashita, Keita Takahashi, Hiroyuki Tanaka, Hiroichi Nagai and Naoki Inagaki
    • Journal Title

      Allergy

      Volume: 67(2) Pages: 201-209

    • DOI

      DOI:10.1111/j.1398-9995.2011.02742.x

    • Peer Reviewed
  • [Presentation] マウス食物アレルギーモデルを用いた経口免疫寛容誘導機序の検討2011

    • Author(s)
      高橋慶多、山下弘高、田中宏幸、永井博弌、稲垣直樹
    • Organizer
      第119回日本薬理学会近畿部会
    • Place of Presentation
      ウィンク愛知(名古屋)
    • Year and Date
      2011-07-08
  • [Presentation] マウス食物アレルギーモデルの作製と経口免疫寛容の解析2011

    • Author(s)
      山下弘高、高橋慶多、田中宏幸、永井博弌、稲垣直樹
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      東日本大震災のため紙面開催
    • Year and Date
      2011-03-31
  • [Presentation] マウス食物アレルギーモデルの作製と基礎的解析2011

    • Author(s)
      山下弘高、高橋慶多、田中宏幸、永井博弌、稲垣直樹
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      東日本大震災のため紙面開催
    • Year and Date
      2011-03-22
  • [Presentation] マウス食物アレルギーモデルを用いた経口免疫寛容の検討2010

    • Author(s)
      山下弘高、高橋慶多、田中宏幸、永井博弌、稲垣直樹
    • Organizer
      第60回アレルギー学会秋季学術大会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2010-11-27

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Published: 2013-07-31  

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