2012 Fiscal Year Final Research Report
Functional analysis of staphylococcal superantigen-like protein
| Project/Area Number |
22790077
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
ITOH Saotomo 名古屋市立大学, 大学院・薬学研究科, 講師 (70308013)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 免疫回避 / 細菌毒素 |
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| Research Abstract |
Staphylococcal superantigen-like (SSL) proteins, composed 14 member of exoprotein, share structural similarity with superantigens but no superantigenic activity. Several SSLs are known to be involved in immune evasion of S. aureus, however remaining SSLs are not identified their target proteins. In this study, we showed that SSL3 binds to TLR2, SSL8 binds to tenascin C, SSL10 binds to phosphatidyl serine and coagulation factors. We also showed the interactions between SSLs and the target proteins interferes the physiological functions of them.
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