2011 Fiscal Year Final Research Report
Studies on the bioactive phospholipids that regulate various proinflammatory responses
| Project/Area Number |
22790084
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 生理活性脂質 / ホスホリパーゼA2 / ケモカイン |
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| Research Abstract |
This research found that 1) the polarity of chemokine-inducible PLX was high compared to sPLA2-IIA inducible PLX, 2) some of the PLX molecules were sensitive to treatment of perchloric acid. Furthermore, 3) the PLX is also involved in the regulation of chemokine expression in LPS-induced septic shock model.
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[Journal Article] Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of Group VIB Ca^<2+>-independent phospholipase A_2y-deficient mice(2010)2010
Author(s)
Yoda E, Hachisu K, Taketomi Y, Yoshida K, Nakamura M, Ikeda K, Taguchi R, Nakatani Y, Kuwata H, Murakami M, Kudo I, Hara S. J.
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Journal Title
Lipid Res
Volume: 51
Pages: 3003-3015
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