2011 Fiscal Year Final Research Report
A novel anti-inflammatory drug targeting purinergic receptors
| Project/Area Number |
22790088
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 免疫学 / 薬学 / プリン受容体 / ATP / 炎症 |
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| Research Abstract |
It is important to establish a novel target of anti-inflammatory drug because immune disease is increasing in all over the world. In this study, I found that P2X7 and P2Y6 purinergic receptors play an important role in activation of T cells and macrophages. The antagonists of these receptors significantly suppressed the increase of pro-inflammatory cytokine levels in sepsis model. I propose that the antagonists of P2X7 and P2Y6 receptors would be candidates of novel anti-inflamatory drug.
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