Regulation of Wnt-3a signaling and diffusion by sulfated glycosaminoglycans

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790095
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Kobe Pharmaceutical University
• Principal Investigator: NADANAKA Satomi 神戸薬科大学, 薬学部, 講師 (60378578)
• Project Period (FY): 2010 – 2011
• Keywords: 生化学 / 糖鎖生物学

Research Abstract

Wnt signaling is implicated in numerous physiological events such as morphogenesis. Here we found cis-acting element implicated in the transcriptional regulation of chondroitin 4-O-sulfotransferase(C4ST-1) gene by Wnt signaling

Research Products

• [Journal Article] Synthesis and interaction with midkine of biotinylated chondroitin sulfate tetrasaccharides (2012)
  • Author(s): Tamura, J., Tsutsumishita-Nakai, N., Nakao, Y., Kawano, M., Kato, S., Takeda, N., Nadanaka, S., and Kitagawa, H.
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 22 Pages: 1371-1374
• [Journal Article] Down-regulation of chondroitin 4-O-sulfotransferase-1 by Wnt signaling triggers diffusion of Wnt-3a (2011)
  • Author(s): Nadanaka, S., Kinouchi, H., Taniguchi-Morita, K., Tamura, J., and Kitagawa, H.
  • Journal Title: J. Biol. Chem. Volume: 286 Pages: 4199-41208
• [Journal Article] Luminal domain of ATF6 alone is sufficient for sensing endoplasmic reticulum stress and subsequent transport to the Golgi apparatus (2011)
  • Author(s): Sato, Y., Nadanaka, S., Okada, T., and Mori, K.
  • Journal Title: Cell Struct. Funct. Volume: 36 Pages: 35-47
• [Journal Article] Regulation of Wnt-3a signaling and diffusion by sulfated glycosaminoglycans (2011)
  • Author(s): Nadanaka, S. and Kitagawa, H.
  • Journal Title: Seikagaku Volume: 83 Pages: 1027-1031
• [Presentation] Down-regulation of Chondroitin 4-O-sulfot ransferase-1 by Wnt Signaling Triggers Di ffusion of Wnt-3a (2011)
  • Author(s): Nadanaka, S., Kinouchi, H., Taniguchi-Morita, K., Tamura, J., and Kitagawa, H.
  • Organizer: 7th International Conference on Proteoglyc ans
  • Place of Presentation: Sydney, Australia
  • Year and Date: 20111016-20
• [Presentation] 硫酸化糖鎖による形態形成因子Wntのシグナル伝達と拡散の調節機構 (2011)
  • Author(s): 灘中里美、染谷健次、宮崎泰太、北川裕之
  • Organizer: 第30回日本糖質学会年会
  • Place of Presentation: 長岡
  • Year and Date: 20110711-13
• [Remarks]
  • URL: http://wwwkobepharma-u.acjp/～biochem/