2011 Fiscal Year Final Research Report
Functional analysis of chondroitin sulfate chains as cel differentiation regulators for regenerative therapies
| Project/Area Number |
22790096
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 糖鎖 / 発現制御 / 発生・分化 / 細胞・組織 / 酵素 |
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| Research Abstract |
Chondroitin sulfate(CS) chains are ubiquitously distributed in extracellular matrices and on cell surfaces in various tissues. Emerging evidence indicates that CS chains play important roles in diverse physiological phenomena such as cell adhesion, proliferation, differentiation, and morphogenesis. In this project, focusing on their potentials as cell differentiation regulators for regenerative therapies, biological functions of CS in "neuritogenesis" and "chondrogenesis" were investigated, and the following findings were obtained. 1) Several CS receptor molecules including contactin-1 are involved in neuroregulatory functions of oversulfated CS variants. 2) Temporally regulated CS expression is required for normal chondrogenic differentiation.
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