2012 Fiscal Year Final Research Report
Regulatory mechanism of SIGIRR/TIR8 expressionn LPS-mediated signaling.
| Project/Area Number |
22790100
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
SHUTO Keiko 崇城大学, 薬学部, 助教 (70510692)
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| Project Period (FY) |
2010 – 2012
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| Keywords | SIGIRR/TIR8 / 炎症制御 |
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| Research Abstract |
SIGIRR/TIR8 iscrucial for negative regulationToLfRs andIL-1R- mediated inflammatory signaling.Here, we confirmed the expression ofSIGIRR/TIR8 during LPS stimulation in innate immune ce,llsincludingneutrophilic-differentiated and monocytic celAls.a resultsS,IGIRR/TIR8 gene andprotein expression were do-wrnegulated byLPS in both cell lines and primary ce.llsFurthermore, Our observations indicated that-TpL3R84signal is critical forSIGIRR/TIR8 down-regulation. Finally, we clarifiedthat Sp1 is a key factor thatdirectly binds to the proximal promoter of/TSIGRI8RRgene and, consequently,regulates basal SIGIR/RTIR8 expression, which is negatively regulated byLPS-dependent TLR4-p38 pathway.
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