2012 Fiscal Year Final Research Report
Development of rapid methylation reaction using polymer supported palladium complex
| Project/Area Number |
22790121
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
IJUIN Ryosuke 独立行政法人理化学研究所, 分子イメージング創薬化学研究チーム, 研究員 (40442925)
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| Project Period (FY) |
2010 – 2012
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| Keywords | PET / 高速化学反応 / クロスカップリング / 陽電子画像診断法 / 固相反応 |
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| Research Abstract |
It is important issue to ensure the safety of PET probes because which is finally give to human clinical study. Carbon-carbon bonding formation is widely used to synthesize PET probes because C-C bond is stable than C-N, C-O or C-S bond in vivo system. Though, in many cases, an organometallic complex is required to form the C-C bond. In order to prevent contamination of the metal complex to the final product for clinical use, solid phase reaction using solid supported palladium complex have examined.
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[Journal Article] Positron emission tomography (PET) imaging-based evaluation of hepatobiliary transport in humans using 15R-[^<11>C]TIC-Me2012
Author(s)
Tadayuki Takashima, Satoshi Kitamura, Yasuhiro Wada, Masaaki Tanaka, Yoshihito Shigihara, Hideki Ishii, Ryosuke Ijuin, Susumu Shiomi, Takahiro Nakae, Yumiko Watanabe, Yilong Cui, Hisashi Doi, Masaaki Suzuki, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe
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Journal Title
J. Nucl. Med.
Volume: 53
Pages: 741-748
DOI
Peer Reviewed
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[Presentation] Evaluation of in vivo Hepatobiliary Transport Using Positron Emission Tomography (PET): Studies in Rats and Application to Microdosing Clinical Studies2011
Author(s)
Tadayuki Takashima, Hiroko Nagata, Hideki Ishii, Ryosuke Ijuin, Takahiro Nakae, Masaaki Tanaka, Yoshihito Shigihara, Suzuka Ataka, Hisashi Doi, Yasuhiro Wada, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama and Yasuyoshi Watanabe
Organizer
9th International ISSX Meeting
Place of Presentation
Istanbul
Year and Date
20110904-08
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