2011 Fiscal Year Final Research Report
Development of GST detection probe, and intracellular drug screening
| Project/Area Number |
22790124
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SHIBATA Aya 独立行政法人理化学研究所, 伊藤ナノ医工学研究室, 基礎科学特別研究員 (50462693)
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| Project Period (FY) |
2010 – 2011
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| Keywords | グルタチオン-S-トランスフェラーゼ / アリールスルフォニル基 / 蛍光プローブ / 化学発光プローブ / ^<19> F-NMRプローブ |
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| Research Abstract |
Our aim is to develop of the probe, which is protected by arylsulfonyl group, for GST detection. The deprotected molecule, which is not a glutathione conjugate, makes it possible to achieve signal cell retention. We succeeded in synthesis of fluorogenic probes, bioluminescent probes, 19F-NMR probes and prodrugs against GST activity.
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[Journal Article] Universal Caging Group for In Cell Detection of Glutathione Transferase Applied to 19F NMR and Bioluminogenic Probes.2012
Author(s)
Ito M., Shibata A., Zhang J., Hiroshima M., Sako Y., Nakano Y., Kojima-Aikawa K., Mannervik B., Shuto S., Ito Y., Morgenstern R. and Abe H.
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Journal Title
ChemBioChem
Volume: (in press)
Peer Reviewed
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[Journal Article] Characterization of new potential anticancer drugs designed to overcome glutathione transferase mediated resistance.2011
Author(s)
Johansson K., Ito M., Schophuizen C. M., Mathew Thengumtharayil S., Heuser V. D., Zhang J., Shimoji M., Vahter M., Ang W. H., Dyson P. J., Shibata A., Shuto S., Ito Y., Abe H. and Morgenstern R.
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Journal Title
Mol. Pharmaceutics
Volume: 8
Pages: 1698-1708
Peer Reviewed
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