2012 Fiscal Year Final Research Report
Development of new cancer therapeutic agents targeting a selective induction of macrophage for cancer cell
| Project/Area Number |
22790126
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
OHNO Akiko 国立医薬品食品衛生研究所, 有機化学部, 主任研究官 (70356236)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 新規抗がん剤 / ガドリニウム / フォスファチジルセリン / MRI |
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| Research Abstract |
A target-specific phagocytes inducing agent for tumor cells was designed and synthesized. The 'eat-me' signal for phagocytes has been proposed to be phosphatidylserine (PS), which is exposed on the surface of dying cells. Gadolinium contrast medium makes certain tissues, abnormalities or disease processes more clearly visible on a magnetic resonance imaging (MRI) scans. The synthesized gadolinium conjugated PS analogues selectively recognized tumor cells. Tne PS accumulated on the surface of tumor cells induces macrophage by acting PS as the ‘ eat me signal’ and the tumor cell were efficiently phagocytosed by macrophages.
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Research Products
(39 results)
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[Journal Article] NMR-based metabolomics of urine in a mouse model of Alzheimer's disease: identification of oxidative stress biomarkers2013
Author(s)
Fukuhara, K., Ohno, A., Ota, Y., Senoo, Y., Maekawa, K., Okuda, H., Kurihara, M., Okuno, A., Niida, S., Saito, Y., Takikawa, O
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Journal Title
J Clin Biochem Nutr
Volume: 52
Pages: 133-138
DOI
Peer Reviewed
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[Journal Article] Reductive amination of glutaraldehyde 2,4-dinitrophenylhydrazone using 2-picoline borane and highperformance liquid chromatographic analysis2012
Author(s)
Uchiyama, S. Sakamoto, H., Ohno, A., Inaba ,Y., Nakagome, H., Kunugita, N.
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Journal Title
Analyst
Volume: 137
Pages: 4274-4279
DOI
Peer Reviewed
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[Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy2012
Author(s)
Demizu, Y., Okuhira, K., Motoi, H., Ohno, A., Shoda, T., Fukuhara, K., Okuda, H., Naito, M., Kurihara, M.
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Journal Title
Bioorg. Med. Chem. Lett.
Volume: 22
Pages: 1793-1796
Peer Reviewed
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[Presentation] Application of a multivariate analysis based on 1H-NMR to new approach for quality evaluation of the protein/peptide biological drugs2010
Author(s)
Ohno, A., Kawasaki, N., Fukuhara, K., Okuda, H., Yamaguchi, T.
Organizer
The 2010 International Chemical Congress of Pacific Basin Societies
Place of Presentation
Honolulu, USA
Year and Date
2010-12-18
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