2011 Fiscal Year Final Research Report
Potential toxicity induced by organotin compounds via PPAR_γsignaling pathway
| Project/Area Number |
22790131
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Kinjo Gakuin University (2011)
Gifu Pharmaceutical University (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | トリフェニルスズ / 胸腺 / PPAR_γ / 脂肪化 |
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| Research Abstract |
TPT administration in the wild-type mice decreased the thymus weight, increased adipose weight and enhanced the mRNA levels of PPAR_γ. aP2 and CD36 in the thymus. Furthermore, TPT promoted the thymic adipogenesis. On the other hand, the effect of TPT administration in PPAR. hetero-knockout mice tended to be lower than the wild-type mice. Flow cytometric analysis demonstrated a significant decrease in the thymus and spleen cell number and a slight decrease in the rate of naive T cell from the thymus. These results suggest that TPT promotes thymic atrophy, adipogenesis and aging via PPAR_γ.
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Research Products
(9 results)
