2013 Fiscal Year Final Research Report
Analysis of physiological roles of adenosine in taste cells
| Project/Area Number |
22790134
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | アデノシン / ATP / 味覚 / 味覚情報伝達 |
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| Research Abstract |
ATP is one of the intercellular signaling molecules in taste buds, and extracellular ATP fate is tightly regulated by its cellular clearance. However, there is a little information on ATPclearance-relating molecules and adenosine receptors in taste buds. Therefore, we examined expression profiles of ecto-nucleotidases, equilibrative nucleoside transporter (ENT) and ARs in rat circumvallate papillae (CP) by immunohistochemistry. ecto-nucleotide pyrophosphatase/phosphodiesterases (ENPP) 3 as a one of the ATP-degradating enzymes, prostatic acid phosphatase (PAP) as a one of the AMP-degradating enzymes, ENT1 as a one of the adenosine transporters, adenosine 2bR (A2bR) were detected in the rat CP. These results indicate that an ATP clearance system mediated by ecto-nucleotidases and ENTs and an adenosine signaling system mediated by A2bR, their coordination being considered to be important for gustatory signaling.
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[Presentation] Expression profile of ecto-nucleotidases and adenosine receptors in rat circumvallate papillae
Author(s)
Kentaro Nishida, Jyunki Kato, Yukari Dohi, Teruyo Kubota, Saki Matsumoto, Ai Miyata, Yuri Yamanaka, Akiko Ikukawa, Katsunobu Tsukamoto, Takaaki Matsuo, Kazuki Nagasawa
Organizer
The 11th Biennial Meeting of the Asian-Pacific Society for Neurochemistry / 55th Annual Meeting of the Japanese Society for Neurochemistry
Place of Presentation
Kobe, Japan
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