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2011 Fiscal Year Final Research Report

The effect of the food contaminants 3-MCPD and glycidol on immune responses

Research Project

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Project/Area Number 22790135
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Environmental pharmacy
Research InstitutionKobe Pharmaceutical University

Principal Investigator

YAMAKI Kouya  神戸薬科大学, 薬学部, 講師 (00351768)

Project Period (FY) 2010 – 2011
Keywords食品汚染物質 / 3-MCPD / グリシドール / 免疫 / T細胞
Research Abstract

We determined the effect of the food contaminants 3-MCPD and glycidol on immune responses. Our results indicated 3-MCPD and its derivative glycidol at or above concentration of 0.3% may potentially affect immune responses. Although the food contaminants at low concentrations in foods in usual might not affect human health, accidental contamination of the compounds at high concentration might affect immune responses upon its intake.

  • Research Products

    (8 results)

All 2012 2011 2010

All Journal Article (5 results) Presentation (3 results)

  • [Journal Article] Tyrosine kinase inhibitor sunitinib relieves systemic and oral antigen-induced anaphylaxes in mice2012

    • Author(s)
      Yamaki K, Yoshino S
    • Journal Title

      Allergy

      Volume: 67 Pages: 114-22

  • [Journal Article] Aspergillus oryzae lectin induces anaphylactoid oedema and mast cell activation through its interaction with fucose of mast cell-bound non-specific IgE2011

    • Author(s)
      Yamaki K, Yoshino S
    • Journal Title

      Scand J Immunol

      Volume: 74 Pages: 445-53

  • [Journal Article] Suppression of antibody-mediated arthritis in mice by Fab fragments of the mediating antibodies2010

    • Author(s)
      Yoshino S, Sasahara M, Hutamekalin P, Yamaki K, Mizutani N, Kuramoto H
    • Journal Title

      Br J Pharmacol

      Volume: 161 Pages: 1351-60

  • [Journal Article] Enhancement of FcεRI-mediated degranulation response in the rat basophilic leukemia cell line RBL2H3 by the fluorosurfactants perfluorooctanoic acid and perfluorooctane sulfonate2010

    • Author(s)
      Yamaki K, Yoshino S
    • Journal Title

      Environ Toxicol Pharmacol

      Volume: 29 Pages: 183-9

  • [Journal Article] Adjuvant effect of zinc oxide on Th2 but not Th1 immune responses in mice2010

    • Author(s)
      Matsumura M, Nagata M, Nakamura K, Kawai M, Baba T, Yamaki K, Yoshino S
    • Journal Title

      Immunopharmacol Immunotoxicol

      Volume: 32 Pages: 56-62

  • [Presentation] マウス食物アレルギーモデルに対するチロシンキナーゼ阻害薬sunitinibの効果2012

    • Author(s)
      八巻耕也、吉野伸
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
  • [Presentation] 環境汚染物質PFOAおよびPFOSによる肥満細胞のメディエーター放出促進2011

    • Author(s)
      八巻耕也、吉野伸
    • Organizer
      第115回日本薬理学会近畿部会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-07-08
  • [Presentation] 肥満細胞のIgE依存的活性化に対する酸化亜鉛ナノ粒子およびマイクロ粒子の抑制作用の比較2011

    • Author(s)
      八巻耕也、吉野伸
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-30

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Published: 2013-07-31  

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