2011 Fiscal Year Final Research Report
Development of a microRNA delivery system for cancer therapy
| Project/Area Number |
22790143
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | ドラッグデリバリー / 核酸医薬 / がん治療 / miRNA |
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| Research Abstract |
Because miRNA/anti-miRNA oligonucleotide(AMO) are considered to be a potential therapeutic tool for cancer, the aim of the study is to development of AMO delivery system based on lipid nanoparticels(NPs). miRNA/AMO were successfully encapsulated in NPs. The systemic administration of NPs modified with functional device for improving intracellular trafficking could induce anti-tumor effect in in vivo tumor-bearing mice model
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Research Products
(28 results)
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[Journal Article] Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid2011
Author(s)
Hatakeyama H, Akita H, Ito E, Hayashi Y, Oishi M, Nagasaki Y, Danev R, Nagayama K, Kaji N, Kikuchi H, Baba Y, Harashima H
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Journal Title
Biomaterials
Volume: 32
Pages: 4306-4316
DOI
Peer Reviewed
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