2011 Fiscal Year Final Research Report
Characterization of "Ribavirin transportsome" in the small intestine
| Project/Area Number |
22790145
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
FURIHATA Tomomi 千葉大学, 大学院・薬学研究院, 助教 (80401008)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 薬物代謝 / 吸収 / リバビリン / C型肝炎 / プリンヌクレオシドホスホリラーゼ |
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| Research Abstract |
The purpose of the present study was to identify a role of purine nucleoside phosphorylase (PNP) in ribavirin absorption. We showed that PNP expressed in human small intestine exclusively metabolized ribavirin to inactive nucleobase. We also showed that the level of PNP activity/expression was one of the determinant factors for the level of ribavirin absorption. Therefore, it can be concluded that PNP plays an important role in determining ribavirin plasma concentration through its metabolizing ability in human small intestine.
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