2012 Fiscal Year Final Research Report
Pharmacogenetics of 6-mercaptopurine maintenance therapy for acutelymphoblastic leukemia in Japanese
| Project/Area Number |
22790170
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | ファーマコジェネティクス / 6-メルカプトプリン / 小児白血病 |
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| Research Abstract |
The genetic polymorphisms of Thiopurine S-methyl transferase (TPMT) and Inosine triphosphate pyrophosphatase (ITPA) were risk factor for increasing frequencies of adverse effects, which are leukopenia and liver toxicity, during maintenance therapy for acute lymphoblastic leukemia (ALL) in Japanese. The genetic mutation of multi-drug resistance protein 4 was increasing frequency of leukopenia during maintenance therapy for ALL.
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Research Products
(9 results)
