2012 Fiscal Year Final Research Report
Neurogenesis in the adult spinal cord by cell fate control
| Project/Area Number |
22790181
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Tohoku University |
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Principal Investigator |
KITADA Masaaki 東北大学, 大学院・医学系研究科, 准教授 (80324614)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脊髄損傷 / グリア前駆細胞 / 上衣細胞 / オリゴデンドロサイト前駆細胞 / 神経細胞新生 |
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| Research Abstract |
We have studied the property of the glial progenitor cells in the adult spinal cord. The ependymal cells in the intact spinal cord expressed the factor A, which was up-regulated after spinal cord injury. We created an adenovirus vector encoding microRNA targeted to the factor A and injected into the ventricle. We found the ependymal cell-derived neurons. The ependymal cells in the adult spinal cord are demonstrated to produce neurons by this cell fate control method.
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[Journal Article] Transplantation of bone marrow stromal cells-derived neural precursor cells ameliorates deficits in a rat model of complete spinal cord transection2013
Author(s)
Aizawa-Kohama M, Endo T, Kitada M, Wakao S, Sumiyoshi A, Matsuse D, Kuroda Y, Morita T, Riera J J, Kawashima R, Tominaga T, Dezawa M.
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Journal Title
Cell Transplant
Volume: (掲載確定)
Peer Reviewed
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[Journal Article] Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques2013
Author(s)
Hayashi T, Wakao S, Kitada M, Ose T, Watabe H, Kuroda Y, Mitsunaga K, Matsuse D, Shigemoto T, Ito A, Ikeda H, Fukuyama H, Onoe H, Tabata Y, Dezawa M.
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Journal Title
J Clin Invest
Volume: 123
Pages: 272-284
DOI
Peer Reviewed
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[Journal Article] Multilineage-differentiatingstress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts2011
Author(s)
Wakao S, Kitada M, Kuroda Y, Shigemoto T, Matsuse D, Akashi H, Tanimura Y, Tsuchiyama K, Kikuchi T, Goda M, Nakahata T, Fujiyoshi Y, Dezawa M.
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Journal Title
Proc Natl Acad Sci USA
Volume: 108
Pages: 9875-9880
DOI
Peer Reviewed
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[Journal Article] Long-term observation of auto-cell transplantation in non-human primate reveals safety and efficiency of bone marrow stromal cell-derived Schwann cells in peripheral nerve regeneration2011
Author(s)
Wakao S, Hayashi T, Kitada M, Kohama M, Matsuse D, Teramoto N, Ose T, Itokazu Y, Koshino K, Watabe H, Iida H, Takamoto T, Tabata Y, Dezawa M.
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Journal Title
Exp Neurol
Volume: 223
Pages: 537-547
DOI
Peer Reviewed
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[Journal Article] Unique multipotent cells in adult human mesenchymal cell populations2010
Author(s)
Kuroda Y, Kitada M, Wakao S, Nishikawa K, Tanimura Y, Makinoshima H, Goda M, Akashi H, Inutsuka A, Niwa A, Shigemoto T, Nabeshima Y, Nakahata T, Nebeshima Y, Fujiyoshi Y, Dezawa M.
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Journal Title
Proc Natl Acad Sci USA
Volume: 107
Pages: 8639-8643
DOI
Peer Reviewed
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[Journal Article] Human umbilical cord-derived mesenchymal stromal cells differentiate into functional Schwann cells that sustain peripheral nerve regeneration2010
Author(s)
Matsuse D, Kitada M, Kohama M, Nishikawa K, Makinoshima H, Wakao S, Fujiyoshi Y, Heike T, Nakahata T, Akutsu H, Umezawa A, Harigae H, Kira J, Dezawa M.
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Journal Title
J Neuropathol Exp Neurol
Volume: 69
Pages: 973-985
DOI
Peer Reviewed
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