2011 Fiscal Year Final Research Report
Transcytosis of cathepsin D in nervous system.
| Project/Area Number |
22790183
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | リソソーム / カテプシン / ライソゾーム病 / セロイドリポフスチノーシス |
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| Research Abstract |
A chick model to monitor the transcytosis of lysosomal enzymes in vivo was developed. I have previously shown that the stable integration of transgenes into chick genome using Tol2 transposition allows to trace astrocytes from the early embryo to late developmental stage near hatching. In this study, a conditional gene knockdown technique driven by U6 promoter using a combination of Cre-loxP system and Tol2 transposition was developed.
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Research Products
(9 results)
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[Journal Article] Intrasulcal electrocorticography in macaque monkeys with minimally invasive neurosurgical protocols2011
Author(s)
Matsuo T, Kawasaki K, Osada T, Sawahata H, Suzuki T, Shibata M, Miyakawa N, Nakahara K, Iijima A, Sato N, Kawai K, Saito N, Hasegawa I
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Journal Title
Front Syst Neurosci
Volume: 5
Pages: 34
Peer Reviewed
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[Journal Article] LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation2010
Author(s)
Shibata M, Yoshimura K, Tamura H, Ueno T, Nishimura T, Inoue T, Sasaki M, Koike M, Arai H, Kominami E, Uchiyama Y
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Journal Title
Biochem Biophys Res Commun
Volume: 393(2)
Pages: 274-9
Peer Reviewed
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