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2011 Fiscal Year Final Research Report

The roles of morphogen during the development of dentate gyrus

Research Project

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Project/Area Number 22790186
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General anatomy (including Histology/Embryology)
Research InstitutionUniversity of Fukui

Principal Investigator

KOMADA Munekazu  福井大学, 医学部, 特命助教 (90523994)

Project Period (FY) 2010 – 2011
Keywordsソニックヘッジホッグシグナル / 大脳皮質 / 中間前駆細胞 / 細胞分化
Research Abstract

Normal morphogenesis of the mammalian cerebral cortex requires orchestration of the proliferation and differentiation of the appropriate number of cells at the appropriate developmental period. Several lines of studies demonstrated that neural stem cells(radial glias : RGs) and neural precursor cells(Intermediate progenitor cells : IPCs) locate in the developing dorsal telencephalon. In particular, IPCs have important roles in the lamination of cerebral cortex layers II and III. We previously reported that Hedgehog(Hh) signaling in the dorsal telencephalon maintains the proliferat ion, survival, and differentiation of RGs and IPCs(Komada et al., 2008). The findings of the present study suggest that Hh signaling controls cell cycle length and regulates the transition from RG to IPCs or neurons and from IPCs to neurons at embryonic day 16. 5 in mice. In the primate cerebral cortex, layers II and III are highly developed and these layers are generated from neurons produced from IPCs. Elucidation of this mechanism is likely to contribute to a better understanding of the constitution of higher brain functions and the pathogenesis of mental disorders.

  • Research Products

    (13 results)

All 2011 2010 Other

All Journal Article (5 results) Presentation (8 results)

  • [Journal Article] Prenatal finding in congenital leukemia : case eport2011

    • Author(s)
      Sato Y., Izumi Y., Minegishi K., Komada M., Yamada S., Kakui K., Tatsumi K., Mikami Y., Fujiwara H., Konishi I.
    • Journal Title

      Fetal Diagnosis and(a) Therapy

      Volume: 29(4) Pages: 325-330

    • DOI

      DOI:10.1159/000323582

  • [Journal Article] Methylnitrosourea induces neural progenitor cell apoptosis and microcephaly in mouse embryos2010

    • Author(s)
      Komada M., Fujiyama F., Yamada S., Shiota K., Nagao T.
    • Journal Title

      Birth Defects Res. B Dev. Reprod. Toxicol

      Volume: 89(3) Pages: 213-222

    • DOI

      DOI:10.10021/bdrb.20245

  • [Journal Article] Hedgehog signaling coordinates the proliferation and differentiation of neural stem/progenitor cells by regulating the cell cycle kinetics during development of the neocortex

    • Author(s)
      Komada M.
    • Journal Title

      Congenital Anomalies

      Volume: (in press)

    • DOI

      DOI:10.1111/j.1741-4520.2012.00368.x

  • [Journal Article] Developmental effects of oral exposure to diethylstilbestrol on mouse placenta

    • Author(s)
      Nagao T., Kagawa N., Saito Y., Komada M.
    • Journal Title

      Journal of Applied Toxicology

      Volume: (in press)

  • [Journal Article] Maternal bisphenol A oral dosing relates to the acceleration of neurogenesis in the developing neocortex of mouse fetuses

    • Author(s)
      Komada M., Asai Y., Morii M., Matsuki M., Sato M., Nagao T.
    • Journal Title

      Toxicology

      Volume: (in press)

    • DOI

      DOI:10.1016/j.tox.2012.02.013

  • [Presentation] Regulation of dendritic spine morphology by FILIP2011

    • Author(s)
      Yagi H., Xie M., Ikeda H., Komada M., Iguchi T., Kuroda K., Okabe M., Sato M.
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-09-17
  • [Presentation] The roles of Hedgehog signaling during the proliferation/differentiation of intermediate progenitor cells2011

    • Author(s)
      Komada M., Iguchi T., Kuroda K., Xie M., Yagi H., Sato M.
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-09-16
  • [Presentation] Dendritic growth activity to resume radial migra(cone) tion properly in the course of multipolar-bipolar transition2011

    • Author(s)
      Xie M., Yagi H., Kuroda K., Komada M., Iguchi T., Sato M.
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-09-15
  • [Presentation] Intermediate progenitorの増殖・分化におけるHedgehogシグナルの役割2011

    • Author(s)
      駒田致和、猪口徳一、黒田一樹、謝敏かく、八木秀司、佐藤真
    • Organizer
      第51回先天異常学会学術集会
    • Place of Presentation
      シェーンバッハ・サボー(東京)
    • Year and Date
      2011-07-23
  • [Presentation] FILIPの新たな側面: FILIP欠損による梨状葉神経細胞棘突起の形態変化2011

    • Author(s)
      八木秀司,謝敏カク,池田弘,駒田致和,猪口徳一,黒田一樹,岡部勝,佐藤真
    • Organizer
      第116回日本解剖学会・全国学術集会
    • Year and Date
      2011-03-30
  • [Presentation] 大脳皮質形成期の法線方向移動における神経細胞の多極性から双極性への形態変化に成長円錐が重要である2011

    • Author(s)
      謝敏カク,黒田一樹,八木秀司,駒田致和,猪口徳一,佐藤真
    • Organizer
      第116回日本解剖学会全国学術集会
    • Year and Date
      2011-03-30
  • [Presentation] 低用量ビスフェノールAのマウス胎児期曝露により誘発される大脳皮質発生異常2010

    • Author(s)
      駒田致和、浅井泰子、守井見奈、長尾哲二
    • Organizer
      第50日本先天異常学会学術集会
    • Place of Presentation
      淡路島夢舞台(兵庫県)
    • Year and Date
      2010-07-08
  • [Presentation] Methylnitrosourea Exposure Induces Apoptosis in the Dorsal Telencephalon and Microcephaly in Mouse Embryos2010

    • Author(s)
      Komada M., Fujiyama F., Yamada S., Shiota K., Nagao T.
    • Organizer
      The Teratology Society 50^<th> Annual Meeting
    • Place of Presentation
      Marriott Louisville Downtown(アメリカ)
    • Year and Date
      2010-06-27

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Published: 2013-07-31  

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