2011 Fiscal Year Final Research Report
Studies on the molecular mechanisms to regulate the connection between blood vessels and lymphatic vessels
Project/Area Number |
22790187
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
General anatomy (including Histology/Embryology)
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Research Institution | Kobe University |
Principal Investigator |
DING Guo 神戸大学, 医学研究科, グローバルCOE研究員 (00514697)
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Project Period (FY) |
2010 – 2011
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Keywords | 発生学 / 形態形成学 |
Research Abstract |
We investigated the formation of venous angles that the physiology connection site between blood vessels and lymphatic vessels. Also we analyzed the abnormal blood-lymph connection in Plcg2^<-/-> mice. Valves in venous angle were consist with blood endothelial cells and lymphatic endothelial cells(LECs) two layers cells. We detected the abnormal blood-lymph connection were randomly present in Plcg2^<-/-> and LEC extends filopodia to blood vessels at connection site. In addition, platelets inhibit proliferation and migration of LECs. Taken together, We proposed new molecular mechanisms : During lymphatic development, Platelets regulate the separation between blood and lymphatic vessel by inhibiting of proliferation and migration, inducing of retraction of lymphatic endothelial cells which encounter to blood vessels during lymphatic sprouting in the peripheral tissue.
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[Journal Article] Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells2012
Author(s)
Osada M, Inoue O, Ding G, Shirai T, Ichise H, Hirayama K, Takano K, Yatomi Y, Hirashima M, Fujii H, Suzuki-Inoue K, Ozaki Y
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Journal Title
J. Biol. Chem
Volume: (in press)
Peer Reviewed
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[Journal Article] Essential in vivo roles of the C-type lectin receptor CLEC-2 : embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets2010
Author(s)
Suzuki-Inoue K, Inoue O, Ding G, Nishimura S, Hokamura K, Eto K, Kashiwagi H, Tomiyama Y, Yatomi Y, Umemura K, Shin Y, Hirashima M, Ozaki Y
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Journal Title
J. Biol. Chem
Volume: 285
Pages: 24494-24507
Peer Reviewed
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[Journal Article] DOCK180 Is a Rac Activator That Regulates Cardiovascular Development by Acting Downstream of CXCR42010
Author(s)
Sanematsu F, Hirashima M, Laurin M, Takii R, Nishikimi A, Kitajima K, Ding G, Noda M, Murata Y, Tanaka Y, Masuko S, Suda T, Meno C, Cote JF, Nagasawa T, Fukui Y
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Journal Title
Circ Res
Volume: 107(9)
Pages: 1102-1105
Peer Reviewed
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