2012 Fiscal Year Final Research Report
Analysis of Rab35 GTPase: insight into cytoskeletal remodeling and membrane trafficking during phagocytosis
| Project/Area Number |
22790188
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Kagawa University |
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Principal Investigator |
EGAMI Youhei 香川大学, 医学部, 助教 (80432780)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ファゴサイトーシス / Rab35 / エフェクター分子 / 細胞骨格 / 膜輸送 / ACAP2 / ARF6 / 蛍光ライブセルイメージング |
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| Research Abstract |
Phagosome formation and subsequent maturation are complex sequences of events that involve actin cytoskeleton remodeling and membrane trafficking. In this study, we found that the Ras-related protein Rab35 is involved in the early stage of FcγR-mediated phagocytosis in macrophages. Our data indicate that Rab35 regulates actin-dependent phagosome formation by recruiting ACAP2, which might control actin remodeling and membrane traffic through ARF6.
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