2011 Fiscal Year Final Research Report
Functional analysis of NLRR-4 gene in the mouse olfactory system during development.
| Project/Area Number |
22790189
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
BANDO Takayoshi 和歌山県立医科大学, 医学部, 学内助教 (00423963)
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| Project Period (FY) |
2010 – 2011
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| Keywords | NLRR-4 / 嗅覚 / 細胞接着分子 |
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| Research Abstract |
In this study, I investigated the expression of NLRR-4 in the olfactory system during development. I found that NLRR-4 was expressed in the olfactory epithelium, olfactory bulb, and piriform cortex. In the vomeronasal organ, NLRR-4 was detected in pheromone receptor V2R-positive-epiterial cells but not in V1R-pisitive cells. In the behavioral analysis, NLRR-4-gene knockout male mice showed reduction of the aggressive responses for the other mile mice and the avoidance behavior for male urine. These results suggested that NLRR-4 was involved in the development of the olfactory system and the function of vomeronasal system.
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