Analysis of Dlg1 function in the development of the cardiac neural crest cells.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22790193
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Gunma University (2012); Fujita Health University (2010-2011)
• Principal Investigator: KOGO Akiko 群馬大学, 大学院・医学系研究科, 助教 (20340242)
• Project Period (FY): 2010 – 2012
• Keywords: 器官形成 / Dlg1 / 心臓 / 神経堤細胞 / コルチ器 / 細胞極性 / マウス

Research Abstract

Dlg1 gene targeted mice exhibit congenital heart defects including outflow tract separation defect and ventricular septal defect. Distribution of cardiac neural crest cells did not exhibit retarded migration. On the other hand, elongation of organ of Corti, intestine, ureter and sternum was insufficient in these mice. As the convergent extension process was recently reported to be needed in the elongation of these tissues and in the outflow tract development, Dlg1 may be involved in the organogenesis through its role in the convergent extension.

Research Products

• [Journal Article] Takao Senda Some fine-structural findings on the thyroid gland in Apc1638T/1638T mice that express a C-terminus lacking truncated Apc (2012)
  • Author(s): Atsushi Yokoyama, Ryuji Nomura, Masafumi Kurosumi, Atsushi Shimomura, Takanori Onouchi, Akiko Iizuka-Kogo, Ron Smits, Riccardo Fodde, Mitsuyasu Itoh
  • Journal Title: Medical molecular morphology Volume: 45 Pages: 161-167
  • Peer Reviewed
• [Journal Article] The C-terminal domain of the adenomatous polyposis coli (Apc)protein is involved in thyroidmorphogenesis and function (2011)
  • Author(s): Atsushi Yokoyama, Ryuji Nomura, Masafumi Kurosumi, Atsushi Shimomura, Takanori Onouchi, Akiko Iizuka-Kogo, Ron Smits, Naohisa Oda, Riccardo Fodde, Mitsuyasu Itoh, Takao Senda
  • Journal Title: Medical Molecular Morphology Volume: 44(4) Pages: 207-212
  • Peer Reviewed
• [Journal Article] Abnormal epithelial cell polarity andectopic epidermal growth factor receptor (EGFR) expression induced in Emx2 KO embryonic gonads (2010)
  • Author(s): Masatomo Kusaka, Yuko Katoh-Fukui, Hidesato Ogawa, Kanako Miyabayashi, Takashi Baba, Noriyuki Sugiyama, Yukihiko Sugimoto, Yasushi Okuno, Ryuji Kodama, Akiko Iizuka-Kogo, Takao Senda, Shinichi Aizawa, Ken-ichirou Morohashi
  • Journal Title: Endocrinology Volume: 151(12) Pages: 5893-904
  • Peer Reviewed
• [Journal Article] High Expression of Pitx-2 in the ICAT-deficient Metanephros Leads to Developmental Arrest (2010)
  • Author(s): Yoshimi Hasegawa, Akiko Iizuka-Kogo, Tetsu Akiyama, and Takao Senda
  • Journal Title: Acta Histochem Cytochem Volume: 43(2) Pages: 51-59
  • Peer Reviewed
• [Presentation] Dlg1は収斂的伸長(convergent extension)機構による組織の伸長に必要である(ポスター) (2013)
  • Author(s): 向後晶子、千田隆夫、松崎利行
  • Organizer: 第118回日本解剖学会総会・全国学術集会サンポートホール高松・かがわ国際会議場
  • Place of Presentation: 高松
  • Year and Date: 2013-03-29
• [Presentation] Dlg1遺伝子欠損マウス表現型の発症メカニズムの解析(ポスター) (2012)
  • Author(s): 向後晶子、日置達也、千田隆夫
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学(甲府)
  • Year and Date: 2012-03-26
• [Presentation] Dlg1KOマウスにおける内耳有毛細胞の異常(口演) (2011)
  • Author(s): 向後晶子、千田隆夫
  • Organizer: 日本解剖学会第71回中部支部学術講演会
  • Place of Presentation: 名古屋大学(名古屋)
  • Year and Date: 2011-10-15
• [Presentation] Dlg1は心臓流出路の中隔形成に必要である(誌上発表) (2011)
  • Author(s): 向後晶子、千田隆夫
  • Organizer: 第116回日本解剖学会総会・全国学術集会
  • Year and Date: 2011-03-28
• [Remarks]
  • URL: http://www.med.gunma-u.ac.jp/med-organization/bioreg/bioreg-metabolism/113.html