Anatomical characteristics of neck analyzed through development of tongue muscle

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790196
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Niigata University (2011); The Institute of Physical and Chemical Research (2010)
• Principal Investigator: NAGASHIMA Hiroshi 新潟大学, 医歯学系, 助教 (40435665)
• Project Period (FY): 2010 – 2011
• Keywords: 脊椎動物 / ボディプラン / 舌筋群 / 頸部

Research Abstract

Vertebrate body is mainly composed of head and trunk, which are combined with neck. To investigate the anatomical characteristics of neck, development of neck region, especially tongue muscles, was compared between various vertebrates. In agnathan, lamprey, anlage of hypobranchial muscle, homologous muscle to tongue muscles in gnathostome, developed behind and under pharyngeal arches. By comparing cephalic neural crest distribution and the anlage, undifferentiated muscle progenitor cells of the tongue muscles appear to develop in the cephalic neural crest just behind the arches. These phenomena were also observed in amniote embryos and confirmed by making chicken-quail chimera in which cephalic neural crest was transplanted. These results indicate that tongue muscles primordium originates from somites and migrates behind and under the arches as undifferentiated scattered cells and differentiates in the cephalic neural crest. In shark, however, the anlage was already differentiated to muscle cells and migrate behind the arches as several segmented streams of cells. This observation indicates that muscle development was secondarily changed in the lineage leading to shark in its evolution and development of fin muscle in shark also does not always shows ancestral state.

Research Products

• [Journal Article] Body plan of turtles : an anatomical, developmental and evolutionary perspective (2012)
  • Author(s): Nagashima, H., Kuraku, S., Uchida, K., Kawashima-Ohya, Y., Narita, Y. and Kuratani, S.
  • Journal Title: Anat. Sci. Int. Volume: 87 Pages: 1-13
• [Journal Article] Hepatocyte growth factor is a crucial factor for development of the carapace in turtles (2011)
  • Author(s): Kawashima-Ohya, Y., Narita, Y., Nagashima, H., Usuda, R. and Kuratani, S.
  • Journal Title: Evol.Dev. Volume: 13 Pages: 260-268
• [Journal Article] Evolutionary developmental perspective for the origin of the turtles : the folding theory for the shell based on the developmental nature of the carapacial ridge (2011)
  • Author(s): Kuratani, S., Kuraku, S. and Nagashima, H.
  • Journal Title: Evol.Dev. Volume: 13 Pages: 1-14
• [Presentation] カメのユニークな形態の比較発生学的解析 (2012)
  • Author(s): 長島寛
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学
  • Year and Date: 2012-03-28
• [Presentation] Developmental Bases for Morphological Diversity of Amniote Pectoral Girdle (2011)
  • Author(s): Nagashima, H.
  • Organizer: The 2011 Annual Meeting of the Society for Molecular Biology & Evolution Symposium 14 : Current problems in vertebrate evolutionary development
  • Place of Presentation: Kyoto University, Kyoto, Japan
  • Year and Date: 2011-07-30
• [Presentation] カメのボディプランについての比較解剖学的、比較発生学的解析 (2011)
  • Author(s): 長島寛
  • Organizer: 第116回日本解剖学会総会・全国学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-03-29
• [Presentation] Turtle evolution by folding of lateral body wall (2010)
  • Author(s): Nagashima, H., Kuraku, S. and Kuratani, S.
  • Organizer: 9th International Congress of Vertebrate Morphology Symposium ; Evolution and development in the lateral plate mesoderm
  • Place of Presentation: Conrad Hotel & Spa, Punta del Este, Uruguay
  • Year and Date: 2010-07-27
• [Book] Developmental basis for innovative evolution of the turtle shell. In R. J. Asher and J. Muller(ed),"From Clone to Bone : the Synergy of Morphological and Molecular Tools in Paleobiology" (2012)
  • Author(s): Kuratani, S. and Nagashima, H., R. J. Asher and J. Muller
  • Publisher: Cambridge University Press, Cambridge.(in press)
• [Book] Origin of the turtle body plan-The folding theory to illustrate turtle-specific developmental repatterning."Morphology and Evolution of Turtles : Origin and Early Diversification" (2012)
  • Author(s): Nagashima, H., Kuraku, S., Uchida, K., Kawashima-Ohya, Y., Narita, Y. and Kuratani, S., D. B. Brinkman, P. A. Holroyd, and J. D. Gardner(in press))
  • Publisher: Springer, Dordrecht