2011 Fiscal Year Final Research Report
Sweet Taste Receptor Expressed in Pancreatic・-Cells is Involved in Novel Insulin Secretion Pathway
| Project/Area Number |
22790200
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Gunma University |
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Principal Investigator |
NAKAGAWA Yuko 群馬大学, 生体調節研究所, 助教 (90422500)
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| Project Period (FY) |
2010 – 2011
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| Keywords | インスリン |
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| Research Abstract |
We analyzed the signal transmission mechanism in the β cell using the sharp system of measurement. As a result, we observed activation of Ca^<2+>, cAMP, diacylglycerol (DAG) and protein kinase C (PKC) being generated instantly in response to glucose stimulation . The response clarified that the new mechanism that was different from the metabolism-dependent reply that had been thought about conventionally in a glucose metabolism-independent object existed.
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