2011 Fiscal Year Final Research Report
The functional analysis of epilepsy related gene TRPP3
Project/Area Number |
22790208
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
General physiology
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2010 – 2011
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Keywords | TRPP3 / TRPチャネル / 小児てんかん |
Research Abstract |
Juvenile myoclonic epilepsy is the most frequently encountered and most common of the generalized epilepsy syndromes. In this research, mutations of the TRPP3 gene were detected in patients with Juvenile myoclonic epilepsy. Heterologous expression and functional analysis revealed abnormality in the 17 kinds of mutant channels.
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[Journal Article] The juvenile myoclonicepilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channellinked to cell death2012
Author(s)
Katano M, Numata T, Aguan K, Hara Y, Kiyonaka S, Yamamoto S, Miki T, Sawamura S, Suzuki T, Yamakawa K, & Mori Y.
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Journal Title
Cell Calcium
Volume: 51(2)
Pages: 179-185
DOI
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[Journal Article] TRPA1 underlies a sensing mechanism for O(2)2011
Author(s)
Takahashi N, Kuwaki T, Kiyonaka S, Numata T, Kozai D, Mizuno Y, YamamotoS, Naito S, Knevels E, Carmeliet P, Oga T, Kaneko S, Suga S, Nokami T, Yoshida J, Mori Y
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Journal Title
Nat ChemBiol
Volume: 7
Pages: 701-711
DOI
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[Journal Article] TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade2010
Author(s)
Koike C, Obara T, Uriu Y, Numata T, SanukiR, Miyata K, Koyasu T, Ueno S, Funabiki K, Tani A, Ueda H, Kondo M, Mori Y, Tachibana M, & Furukawa T
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Journal Title
Proc Natl Acad Sci USA
Volume: 107
Pages: 332-337
DOI
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[Journal Article] Rim2 determins docking and priming states in insulin granule exocytosis2010
Author(s)
Yasuda T, Shibasaki T, Minami K, TakahashiH, Mizoguchi A, Uriu Y, Numata T, Mori Y, Miyazaki J, Miki T, & Seino S
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Journal Title
Cell Metabolism
Volume: 4
Pages: 117-129
DOI
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