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2011 Fiscal Year Final Research Report

The functional analysis of epilepsy related gene TRPP3

Research Project

  • PDF
Project/Area Number 22790208
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General physiology
Research InstitutionKyoto University

Principal Investigator

NUMATA Tomohiro  京都大学, 地球環境学堂, 助教 (20455223)

Project Period (FY) 2010 – 2011
KeywordsTRPP3 / TRPチャネル / 小児てんかん
Research Abstract

Juvenile myoclonic epilepsy is the most frequently encountered and most common of the generalized epilepsy syndromes. In this research, mutations of the TRPP3 gene were detected in patients with Juvenile myoclonic epilepsy. Heterologous expression and functional analysis revealed abnormality in the 17 kinds of mutant channels.

  • Research Products

    (25 results)

All 2012 2011 2010 Other

All Journal Article (11 results) Presentation (11 results) Book (2 results) Remarks (1 results)

  • [Journal Article] The juvenile myoclonicepilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channellinked to cell death2012

    • Author(s)
      Katano M, Numata T, Aguan K, Hara Y, Kiyonaka S, Yamamoto S, Miki T, Sawamura S, Suzuki T, Yamakawa K, & Mori Y.
    • Journal Title

      Cell Calcium

      Volume: 51(2) Pages: 179-185

    • DOI

      DOI:10.1016/j.ceca.2011.12.011

  • [Journal Article] The Csplice-variant of TRPM2 is the hypertonicity-induced cation channel(HICC) in HeLa cells, and the ecto-enzyme CD38mediates its activation2012

    • Author(s)
      Numata T, Sato K, Christmann J, Marx R, Mori Y, Okada Y, Wehner F
    • Journal Title

      J Physiology

      Volume: 590 Pages: 1121-1138

    • DOI

      DOI:10.1113/jphysiol.2011.220947

  • [Journal Article] Involvements of the ABC protein ABCF2 andα-actinin-4 in regulation of cell volume and anion channels in human epithelial cells2012

    • Author(s)
      Ando-Akatsuka Y, Shimizu T, Numata T, Okada Y
    • Journal Title

      J Cell Physiol

    • DOI

      DOI:10.1002/jcp.24050

  • [Journal Article] Utilization of Photo induced Charge-Separated State of Donor-Acceptor Linked Molecules for Regulation of Cell Membrane Potential and Ion Transport2012

    • Author(s)
      Numata T, Murakami T, Kawashima F, Morone N, Heuser JE, Takano Y, Ohkubo K, Fukuzumi S, Mori Y, Imahori H
    • Journal Title

      J Am Chem Soc

      Volume: 134 Pages: 6092-6095

    • DOI

      DOI:10.1021/ja3007275

  • [Journal Article] V2 Receptor-Mediated Autocrine Role of Somatodendritic Release of AVP in Rat Vasopressin Neurons Under Hypo-Osmotic Conditions2011

    • Author(s)
      Sato K, Numata T, Saito T, Ueta Y, & Okada Y
    • Journal Title

      Sci Signal

      Volume: 4

    • DOI

      DOI:10.1126/scisignal.2001279

  • [Journal Article] TRPA1 underlies a sensing mechanism for O(2)2011

    • Author(s)
      Takahashi N, Kuwaki T, Kiyonaka S, Numata T, Kozai D, Mizuno Y, YamamotoS, Naito S, Knevels E, Carmeliet P, Oga T, Kaneko S, Suga S, Nokami T, Yoshida J, Mori Y
    • Journal Title

      Nat ChemBiol

      Volume: 7 Pages: 701-711

    • DOI

      DOI:10.1038/nchembio.640

  • [Journal Article] Expression of N-type calcium channels in human adrenocortical cells and their contribution to corticosteroid synthesis2011

    • Author(s)
      Aritomi S, Wagatsuma H, Numata T, Uriu Y, Nogi Y, Mitsui A, Konda T, Mori Y, & Yoshimura M
    • Journal Title

      Hypertention Research

      Volume: 34 Pages: 193-201

    • DOI

      DOI:10.1038/hr.2010.191

  • [Journal Article] TRPM1 : A vertebrate TRP channel responsible for retinal ON bipolar function2010

    • Author(s)
      Koike C, Numata T, Ueda H, Mori Y, & Furukawa T
    • Journal Title

      Cell Calcium

      Volume: 48 Pages: 95-101

    • DOI

      DOI:10.1016/j.ceca.2010.08.004

  • [Journal Article] TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade2010

    • Author(s)
      Koike C, Obara T, Uriu Y, Numata T, SanukiR, Miyata K, Koyasu T, Ueno S, Funabiki K, Tani A, Ueda H, Kondo M, Mori Y, Tachibana M, & Furukawa T
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 107 Pages: 332-337

    • DOI

      DOI:10.1073/pnas.0912730107

  • [Journal Article] Rim2 determins docking and priming states in insulin granule exocytosis2010

    • Author(s)
      Yasuda T, Shibasaki T, Minami K, TakahashiH, Mizoguchi A, Uriu Y, Numata T, Mori Y, Miyazaki J, Miki T, & Seino S
    • Journal Title

      Cell Metabolism

      Volume: 4 Pages: 117-129

    • DOI

      DOI:10.1016/j.cmet.2010.05.017

  • [Journal Article] The modulation of TRPM7 currents by nafamostat mesilatedepends directly upon extracellular concentrations of divalent cations2010

    • Author(s)
      Chen X, Numata T(co-first author), Li M, Mori Y, Orser BA, Jackson MF, Xiong ZG, & Macdonald JF
    • Journal Title

      Mol Brain

      Volume: 3 Pages: 38

    • DOI

      DOI:10.1186/1756-6606-3-38

  • [Presentation] TRPA1は体内への酸素供給を制御する酸素センサーである2012

    • Author(s)
      高橋重成、桑木共之、清中茂樹、沼田朋大、森泰生
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館
    • Year and Date
      20120329-31
  • [Presentation] Ca^<2+>チャネル点変異マウスtotteringの海馬における癲癇様オシレーションの発生機序解明2012

    • Author(s)
      中尾章人、三木崇史、下野健、沼田朋大、清中茂樹、若森実、森泰生
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館
    • Year and Date
      20120329-31
  • [Presentation] 熱性けいれん患者において発見されたHCN2変異は温度依存的な活性を変化させる2012

    • Author(s)
      中村友紀、石秀玉、沼田朋大、森泰生、井上隆司、廣瀬伸一
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館
    • Year and Date
      20120329-31
  • [Presentation] TRPA1チャネルの酸素感受機構の解明2012

    • Author(s)
      沼田朋大、高橋重成、清中茂樹、香西大輔、森泰生
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館
    • Year and Date
      20120329-31
  • [Presentation] The juvenile myoclonicepilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death2012

    • Author(s)
      Tomohiro Numata
    • Organizer
      第一回多階層生体機能学HD Physiology国際シンポジウム
    • Place of Presentation
      東京大学武田先端知ビル武田ホール
    • Year and Date
      20120120-21
  • [Presentation] 酸感受性外向整流性クロライドチャネル分子実体の探究2012

    • Author(s)
      佐藤かお理、沼田朋大、リーエルバート、岡田泰伸
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館
    • Year and Date
      2012-03-29
  • [Presentation] TRPM7 is an essential regulator for the volume-sensitive outwardly rectifying anion channel(VSOR) activity2011

    • Author(s)
      Tomohiro Numata, Kaori Sato, Carsten Schmitz, Meredith C. Hermosura, Anne-Laure Perraud, Yasuo Mori, Yasunobu Okada
    • Organizer
      The 7th Congress of the Federation of Asian and Oceanian Physiological Societies(FAOPS)
    • Place of Presentation
      Taipei(Taiwan)
    • Year and Date
      20110911-14
  • [Presentation] 熱性けいれん患者において発見されたHCN2遺伝子変異は温度依存的な活性を変化させる2011

    • Author(s)
      中村友紀、石秀玉、沼田朋大、森泰生、井上隆司、廣瀬伸一
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      20110328-30
  • [Presentation] TRPM1は網膜ON型双極細胞の視覚伝達チャネルである2011

    • Author(s)
      沼田朋大、小池千恵子、上田浩、森泰生、古川貴久
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      20110328-30
  • [Presentation] 低浸透圧条件下におけるVSOR Cl.チャネルとTRPM7チャネルの機能連関2011

    • Author(s)
      沼田朋大, 佐藤かお理, Carsten Schmitz, Meredith C. Hermosura, Anne-Laure Perraud, 森泰生, 岡田泰伸
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      20110328-30
  • [Presentation] A pathogenic Cterminus-truncated polycystin-2 mutationenhances receptor-activated Ca2+entry viaassociation with TRPC3 and TRPC7 Japan Canada Symposium2010

    • Author(s)
      Numata T
    • Place of Presentation
      Convergence Centre Boardroom, Windermere, London, Canada
    • Year and Date
      20100512-13
  • [Book] トランスポトソームの世界-膜輸送研究の源流から未来へ2011

    • Author(s)
      森泰生, 沼田朋大, 高橋重成(2-4-1総論), 沼田朋大
    • Publisher
      京都廣川書店
  • [Book] Activation of TRP channelsin mammalian systems2011

    • Author(s)
      Numata, T., Kiyonaka S, Kato K, Takahashi N, & Mori Y.
    • Publisher
      Taylor & Francis Group
  • [Remarks]

    • URL

      http://www.sbchem.kyoto-u.ac.jp/mori-lab/member/numata.html

URL: 

Published: 2013-07-31  

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