2011 Fiscal Year Final Research Report
Abnormal circulatory function in TRIC-A-knockout mice
| Project/Area Number |
22790209
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Kyoto University |
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Principal Investigator |
YAMAZAKI Daiju 京都大学, 生理化学研究ユニット, 特定講師 (40467428)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 微小循環 / 末梢循環 / 循環力学 / 循環調節 / カウンターイオン / カルシウム |
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| Research Abstract |
The aim of this project is to examine the pathogenic mechanism of abnormal circulatory function such as hypertension and isoproterenol(Iso) induced hypertrophy in TRIC-A-knockout mice. It was found that hypertension was caused by abnormality of vascular tonus regulation in TRIC-A-knockout vascular smooth muscle cells. On the other hand, cardiac fibrosis but not hypertrophy was significantly induced by Iso infusion using osmotic pump in TRIC-A-knockout mice. Unfortunately, it was unclear the mechanism of cardiac fibrosis during research period. We will try to examine this project in another one.
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[Journal Article] TRIC-A Channels in Vascular Smooth Muscle Contribute to Blood Pressure Maintenance2011
Author(s)
Yamazaki D, Tabara Y, Kita S, Hanada H, Komazaki S, Naitou D, Mishima A, Nishi M, Yamamura H, Yamamoto S, Kakizawa S, Miyachi H, Yamamoto S, Miyata T, Kawano Y, Kamide K, Ogihara T, Hata A, Umemura S, Soma M, Takahashi N, Imaizumi Y, Miki T, Iwamoto T & T
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Journal Title
Cell Metabolism
Volume: 14
Pages: 231-241
DOI
URL
Peer Reviewed
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