2011 Fiscal Year Final Research Report
Chloride dynamics in beating cardiomyocytes
| Project/Area Number |
22790211
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Kyoto University |
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Principal Investigator |
KIM Uongju 京都大学, 医学研究科, 特定研究員 (80511823)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 未熟・成熟B細胞 / ミトコンドリア / 膜結合型B細胞レセプター / ミトコンドリアCa2+輸送体 / 細胞質Ca2+ |
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| Research Abstract |
The purpose of the present study was to clarify the role of mitochondrial NCX in BCR-mediated Ca2+response on B lymphocytes. To achieve these goals, cell physiological experiments were performed and the following results were obtained. 1. Technique to measure the mitochondria and ER Ca2+was established. 2. Expression of NCLX, the mitochondrial NCX, was analyzed in DT40 B cells. 3. Mitochondrial NCX supports ER Ca2+filling and pivotal in BCR-mediated Ca2+signaling in B lymphocytes.
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[Journal Article] Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity2011
Author(s)
Otsuka A, Kubo M, Honda T, Egawa G, Nakajima S, Tanizaki H, Kim B, Matsuoka S, Watanabe T, Nakae S, Miyachi Y, Kabashima K.
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Journal Title
Peer Reviewed
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