2011 Fiscal Year Final Research Report
Functional analysis of Ror2 in neurogenesis and astrogenesis
| Project/Area Number |
22790213
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Kobe University |
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Principal Investigator |
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| Research Collaborator |
DOI Ryosuke 神戸大学, 医学研究科, 大学院生
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| Project Period (FY) |
2010 – 2011
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| Keywords | 神経系前駆細胞 / Wntシグナル / Ror受容体 / 未分化性維持 / ニューロン産生 / アストロサイト |
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| Research Abstract |
Although the Ror-family of receptor tyrosine kinases, Ror2, and its ligand Wnt5a are expressed in the developing brain, little is known about their roles in the neural development. We show that Ror2 and Wnt5a are highly expressed in neocortical neural progenitor cells(NPCs) and that Wnt5a. Ror2 signaling plays essential role in maintaining neurogenic NPCs during neurogenesis of the developing neocortex.
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