2011 Fiscal Year Final Research Report
Physiological roles of NALCN channel, the sodium leak channel, in the heart
| Project/Area Number |
22790217
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Kurume University (2011)
Jichi Medical University (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | イオンチャネル / 心ペースメーカー細胞 / 持続性内向き電流 / NALCN |
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| Research Abstract |
In this study, we tried to elucidate the molecular mechanisms underlying sustained inward current(Ist), a pacemaker cell specific current in sinoatrial node. RT-PCR analysis revealed that the recently identified new Cav1.3(1b) isoform was specifically expressed in the sinoatrial node, but not Cav1.3(1a). Heterologous expression of Cav1.3(1b) in Xenopus oocytes induced Ca^<2+> currents, but failed to induce Na^+currents similar to Ist.
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[Journal Article] Pathophysiological remodeling of mouse cardiac myocytes expressing dominant negative mutant of neuron restrictive silencing factor2010
Author(s)
Takano, M., Kinoshita, H., Shioya, T., Itoh, M., Nakao, K., and Kuwahara, K.
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Journal Title
Circ. J
Volume: 74
Pages: 2712-2719
Peer Reviewed
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