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2011 Fiscal Year Final Research Report

Cellular and molecular mechanism of hormone sensing on vagal afferents and its linking to the feeding

Research Project

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Project/Area Number 22790218
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General physiology
Research InstitutionJichi Medical University

Principal Investigator

IWASAKI Yusaku  自治医科大学, 医学部, 助教 (60528420)

Project Period (FY) 2010 – 2011
Keywords迷走神経求心路 / nodose ganglion / 摂食 / ホルモン / インスリン / グレリン / GLP-1
Research Abstract

Vagal afferents sense the peripheral factors and convey these signals to the brain to regulate food intake. In present study, I measured cytosolic Ca^<2+> concentration in the primary cultured neurons of vagal afferents to investigate whether peripheral factor directly act on the vagal afferents. We have found that some of pancreatic and gastrointestinal hormones activate vagal afferents neurons directly. Moreover, the insulin action to vagal afferent neurons was suppressed by ghrelin and potentiated by GLP-1.

  • Research Products

    (2 results)

All 2011 2010

All Presentation (2 results)

  • [Presentation] インスリンの求心性迷走神経への直接作用とグレリン、GLP-1との相互作用2011

    • Author(s)
      岩崎有作
    • Organizer
      第32回日本肥満学会
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県)
    • Year and Date
      20110923-24
  • [Presentation] インスリンによる求心性迷走神経細胞活性化とシグナル伝達2010

    • Author(s)
      岩崎有作
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      前橋プラザ元気21(群馬県)
    • Year and Date
      20101001-02

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Published: 2013-07-31  

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