2011 Fiscal Year Final Research Report
The mechanism of function and regulation of TASK channels in endocrine cells
| Project/Area Number |
22790222
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | TASKチャネル / エンドサイトーシス / PC12細胞 / NGF / Src / クラスリン |
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| Research Abstract |
I investigated the molecular mechanism of regulation of TASK1 channels in endocrine cells. Pharmacological and molecular biological analyses showed that TASK1 channels are regulated by the clathrin-dependent endocytosis in NGF-stimulated adrenal medullary and PC12 cells. Furthermore, it was suggested that NGF-induced endocytosis of TASK1 channels is regulated by its posttranslational modification through activation of Src and the direct or indirect effects of activation of both PLCγand PI3 kinase.
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Research Products
(8 results)
