2012 Fiscal Year Final Research Report
Characterization of extra-nuclear estrogen receptors in the central nervous system.
| Project/Area Number |
22790229
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 生殖生理学 / 神経内分泌学 / 生物物理学 / ホルモン / ステロイド / エストロゲン / エストロゲン受容体 / 脳ニューロステロイド |
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| Research Abstract |
This research was planned to characterize extra-nuclear estrogen receptors that mediate non-genomic effects of estrogens in the central nervous system. The genomic organization of human, mouse, and rat estrogen receptor α (ERα) genes was re-examined. The analysis revealed more complicated genomic structures of the ERα genes and localization of novel promoters and exons in the 5’-, intronic and 3’-regions of the genes. Furthermore, the analysis demonstrated that alternative promoter usage and alternative splicing generated numerous mRNA variants that encoded N-terminally- and C-terminally-truncated estrogen receptors. The variant proteins exhibited distinct functional properties and cellular localization compared with those of the wild-type ERα proteins.
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[Journal Article] Endogenous synthesis of corticosteroids in the hippocampus2012
Author(s)
Higo S, Hojo Y, Ishii H, Komatsuzaki Y, Ooishi Y, Murakami G, Mukai H, Yamazaki T, Nakahara D, Barron A, Kimoto T, Kawato S
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Journal Title
PLoS One
Volume: 6
Pages: 21631
DOI
Peer Reviewed
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[Journal Article] Hippocampal synthesis of sex steroids andcorticosteroids: essential for modulation of synaptic plasticity.2011
Author(s)
Hojo Y, Higo S, Kawato S, Hatanaka Y, Ooishi Y, Murakami G, Ishii H, Komatsuzaki Y, Ogiue-Ikeda M, Mukai H, Kimoto T
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Journal Title
Frontiers in Endocrinology
Volume: 2
Pages: 43
DOI
Peer Reviewed
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