2011 Fiscal Year Final Research Report
Development of imaging technique for D-serine dynamics in central nervous system
| Project/Area Number |
22790244
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | D-セリン / 蛍光イメージング |
|---|
| Research Abstract |
D-serine is known to regulate synaptic functions in a central nervous systems(CNS). However, spatiotemporal dynamics of D-serine in CNS remains unclear. In this study, we aimed to develop a novel fluorescent probes for visualizing D-serine dynamics. For this purpose, we established high throughput screening system for the development of fluorescent probe. By using this technical platform, we obtained several candidate fluorescent conjugates for D-serine probes which are expected to show a large fluorescence change upon D-serine binding.
|
-
[Journal Article] Adiponectin and AdipoR1 regulate PGC-1・and mitochondria by Ca^<2+> and AMPK/SIRT12010
Author(s)
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T,
-
Journal Title
Nature
Volume: 464
Pages: 1313-1319
DOI
Peer Reviewed
-
-
-
-
