2011 Fiscal Year Final Research Report
Research on neural plasticity and molecular basis underlying emotional behaviors with emphasis on roles of inflammation-related molecules
| Project/Area Number |
22790249
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 中枢 / 末梢神経 |
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| Research Abstract |
Chronic stress causes emotional changes, such as depression and anxiety. However, the underlying mechanism remains unknown. We have employed repeated social defeat stress, a mouse model of major depression, and have shown that prostaglandin(PG) E2 and its receptor EP1 mediate emotional changes by chronic stress through attenuation of prefrontal dopaminergic activity. Further, cyclooxygenase(COX) 1, a PG synthase expressed in microglia in the brain, is critical for emotional changes by repeated social defeat, suggesting a potential role of PGE2 synthesis in microglia.
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[Journal Article] Ito, J. Role of PGE-type receptor 4 in auditory function and noise-induced hearing loss in mice2012
Author(s)
Hamaguchi, K., Yamamoto, N., Nakagawa, T., Furuyashiki, T., Narumiya, S.
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Journal Title
Neuropharmacology
Volume: 62
Pages: 1841-1847
DOI
Peer Reviewed
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[Journal Article] A role for mDia, a Rho-regulatedactin nucleator, in tangential migration of interneuron precursors2012
Author(s)
Shinohara, R., Thumkeo, D., Kamijo, H., Kaneko, N., Sawamoto, K., Watanabe, K., Takebayashi, H., Kiyonari, H., Ishizaki, T., Furuyashiki, T., Narumiya, S.
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Journal Title
Nat. Neurosci.
Volume: 15
Pages: 373-380
DOI
Peer Reviewed
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[Journal Article] Prostaglandin E2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice2012
Author(s)
Tanaka, K., Furuyashiki, T., Kitaoka, S., Senzai, Y., Imoto, Y., Segi-Nishida, E., Deguchi, Y., Breyer, R. M., Breyer, M. D., Narumiya, S.
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Journal Title
J. Neurosci
Volume: 32
Pages: 4319-4329
DOI
Peer Reviewed
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[Journal Article] PGE2-EP2 receptor signaling in endothelium is activated by hemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-κB.2011
Author(s)
Aoki, T., Nishimura, M., Matsuoka, T., Yamamoto, K., Furuyashiki, T., Kataoka, H., Kitaoka, S., Ishibashi, R., Ishibazawa, A., Miyamoto, S., Morishita, R., Ando, J., Hashimoto, N., Nozaki, K., Narumiya, S.
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Journal Title
Br. J. Pharmacol
Volume: 163
Pages: 1237-1249
DOI
Peer Reviewed
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[Journal Article] CentralPGE2 exhibits anxiolytic-like activityvia EP1 and EP4 receptros in a mannerdependent on serotonin 5-HT1A, dopamine DS1 and GABAA receptor2011
Author(s)
Suzuki, C., Miyamoto, C., Furuyashiki, T., Narumiya, S., Ohinata, K.
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Journal Title
FEBS Lett.
Volume: 585
Pages: 2357-2362
DOI
Peer Reviewed
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[Journal Article] Thromboxane receptor activation enhances striatal dopamine release leading to suppression of GABAergictransmission and enhanced sugarintake.2011
Author(s)
Mitsumori, T., Furuyashiki, T., Momiyama, T., Nishi, A., Shuto, T., Hayakawa, T., Ushikubi, F., Kitaoka, S., Aoki, T., Inoue, H., Matsuoka, T., Narumiya, S.
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Journal Title
Eur. J. Neurosci.
Volume: 34
Pages: 594-604
DOI
Peer Reviewed
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[Journal Article] Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia
Author(s)
Thumkeo, D., Shinohara, R., Watanabe, K., Takebayashi, H., Toyoda, Y. Tohyama, K., Ishizaki, T., Furuyashiki T., Narumiya, S.
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Journal Title
DOI
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