2011 Fiscal Year Final Research Report
A New Approach to Searching for the Bioactive Molecules Regulating Potassium Channel
| Project/Area Number |
22790250
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 内向き整流性カリウムチャネル / ファーマコフォア / スフィンゴ脂質 / 電気生理学 / 薬理学 |
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| Research Abstract |
This study aimed to explore a novel bioactive molecule that regulate ion channel function by in silico screening with a pharmacophore model of its chemical ligands. Sphingosine fits the pharmacophore model for inwardly rectifier potassium(Kir) channel 4. 1 blockers. Sphingosine has an inhibitory effect on Kir4. 1 channels. When biosynthesis of sphingosine from sphingomyeline via ceramide is stimulated, Kir4. 1 channel currents decrease. These results suggest that endogenous sphingolipids inhibit Kir4. 1 channels via sphingosine.
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[Journal Article] Ca^<2+> entry mode of Na^+/ Ca^<2+> exchanger as a new therapeutic target for heart failure with preserved ejection fraction2012
Author(s)
Daisuke Kamimura, Tomohito Ohtani, Yasushi Sakata, Toshiaki Mano, Yasuharu Takeda, Shunsuke Tamaki, Yosuke Omori, Yasumasa Tsukamoto, Kazuharu Furutani, Yutaka Komiyama, Masamichi Yoshika, Hakuo Takahashi, Toshio Matsuda, Akemichi Baba, Satoshi Umemura, Takeshi Miwa, Issei Komuro, Kazuhiro Yamamoto
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Journal Title
European Heart Journal
Volume: (in press)
Peer Reviewed
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