2011 Fiscal Year Final Research Report
Search for new antiarrhythmic drugs based on inhibition of trigger in atrial fibrillation
| Project/Area Number |
22790251
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 心臓 / 不整脈 / 抗不整脈 / 心房細動 |
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| Research Abstract |
In this study, in order to facilitate the development of new antiarrhythmic drugs specific for atrial fibrillation, we studied the potential of TRPM4 channel inhibitors antiarrhythmic drugs. TRPM4 channel can be activated by elavated intracellular Ca^<2+> con(as) cen(new) tration and therefore can be triggers for atrial fibrillation, Since TRPM4 channels are not functional in the human ventricular, selective inhibitors of TRPM4 channels are expected to cause limited side effect in the ventricular. By using the human atrial model and TRPM4 channel model, we showed that inhibitors of TRPM4 channel may suppress atrial fibrillation and may be a good candidate for new antiarrhythmic drugs.
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