2011 Fiscal Year Final Research Report
A potential treatment of glaucoma by glia-derived lipoproteins.
| Project/Area Number |
22790254
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Kumamoto University |
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Principal Investigator |
HAYASHI Hideki 熊本大学, 大学院・先導機構, 特任助教 (90508657)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 緑内障 / リポプロテイン |
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| Research Abstract |
Glaucoma is the leading cause of blindness in Japan. Thus, the aims of this study are to analyze mechanisms of developing glaucoma and neuroprotection by glia-derived lipoproteins. Glaucoma induces degeneration of retinal ganglion cells(RGCs), so we determined whether lipoproteins were able to protect primary cultured RGCs from degeneration induced by glutamate. This study demonstrated that lipoproteins protected RGCs from apoptosis by preventing calcium overload.
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[Journal Article] Dynamic imaging of axonal transport in living retinal ganglion cells in vitro2011
Author(s)
Takihara, Y., Inatani, M., Hayashi, H., Adachi, N., Iwao, K., Inoue, T., Iwao, M., and Tanihara, H.
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 52
Pages: 3039-3045
Peer Reviewed
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