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2012 Fiscal Year Final Research Report

Spatio-temporal analysis of intracellularcalcium oscillation in the pulmonary vein myocardium

Research Project

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Project/Area Number 22790262
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionToho University

Principal Investigator

NAMEKATA Iyuki  東邦大学, 薬学部, 講師 (30510309)

Research Collaborator TANAKA Hikaru  東邦大学, 薬学部, 教授 (40236617)
TAKAHARA Akira  東邦大学, 薬学部, 准教授 (80377481)
KAWANISHI Toru  国立衛生試験所, 部長 (40124383)
TANAKA Naoko  大妻女子大学, 家政学部, 教授 (40184353)
Project Period (FY) 2010 – 2012
Keywords薬理学 / 肺静脈心筋 / カルシウムイメージング / 自動能 / 心房細動
Research Abstract

We assessed the electrophysiological properties of pulmonary vein myocardium and analyzed its arrhythmogenic activity. Some of the pulmonary vein cardiomyocytes, but not atrial cardiomyocytes, showed sustained spontaneous Ca2+transients. But morphology and the sarcoplasmic reticulum content of pulmonary vein cardiomyocytes were the same as those of atrial myocytes. The pulmonary vein myocardium had a less negative resting membrane potential and lower density of inwardly rectifying potassium current than atrial. These results suggest that the lower density of repolarizing currents in pulmonary vein cardiomyocytes appears to play a permissive role for depolarization induced by elevation of intracellular Ca2+.

  • Research Products

    (23 results)

All 2013 2012 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (14 results) Remarks (1 results)

  • [Journal Article] Electrophysiological and pharmacologi- cal properties of the pulmonary vein myocardium.2013

    • Author(s)
      Iyuki Namekata, Yayoi Tsuneoka, Hikaru Tanaka.
    • Journal Title

      Biol Pharm Bull.

      Volume: 36 (1) Pages: 2-7

    • DOI

      DOI:http://dx.doi.org/10.1248/bpb.b212020

    • Peer Reviewed
  • [Journal Article] Electrical activity of the mouse pulmonary vein myocardium.2012

    • Author(s)
      Yayoi Tsuneoka, Yuka Kobayashi, Yoriko Honda, Iyuki Namekata, Hikaru Tanaka.
    • Journal Title

      J. Pharmacol Sci.

      Volume: 119(3) Pages: 287-292

    • DOI

      DOI: http://dx.doi.org/10.1254/jphs.12062SC

    • Peer Reviewed
  • [Journal Article] Electrophysiological effects of the class Ic antiarrhythmic drug pilsicainide on the guinea-pig pulmonary vein myocardium.2012

    • Author(s)
      Akira Takahara, Kiyoshi Takeda, Yayoi Tsuneoka, Miyoko Hagiwara, Iyuki Namekata,Hikaru Tanaka.
    • Journal Title

      J. Pharmacol Sci.

      Volume: 118 (4) Pages: 506-511

    • DOI

      DOI:http://dx.doi.org/10.1254/jphs.12022FP

    • Peer Reviewed
  • [Journal Article] Electrophysiological and pharmacological characteristics of triggered activity elicited in the guinea-pig pulmonary vein myocardium.2011

    • Author(s)
      Akira Takahara, Takahiko Sugimoto, Takuma Kitamura, Kiyoshi Takeda, Yayoi Tsuneoka, Iyuki Namekata, Hikaru Tanaka
    • Journal Title

      J. Pharmacol Sci.

      Volume: 115(2) Pages: 176-81

    • DOI

      DOI: http://dx.doi.org/10.1254/jphs.10232FP

    • Peer Reviewed
  • [Journal Article] Electropharmacological properties of the pulmonary vein myocardium.2011

    • Author(s)
      Hikaru Tanaka, Yayoi Tsuneoka, Iyuki Namekata.
    • Journal Title

      Current Topics in Pharmacology.

      Volume: 15 (2) Pages: 19-24

    • URL

      http://www.researchtrends.net/tia/abstract.asp?in=2&vn=15&tid=11&aid=3475&pub=2011&type=

  • [Journal Article] Cardioprotective effects of Na+-Ca2+exchanger inhibition.2011

    • Author(s)
      Iyuki Namekata, Hikaru Tanaka.
    • Journal Title

      Recent Research Developments in Pharmacology.

      Volume: Vol2 Pages: 115-126

    • URL

      http://ressign.com/UserArticleDetails.aspx?arid=11370

  • [Journal Article] Intracellular calcium and membrane potential oscillations in the guinea-pig and rat pulmonary vein myocardium.2010

    • Author(s)
      Iyuki Namekata, Yayoi Tsuneoka, Akiko Akiba, Hideki Nakamura, Hideaki Shimada, Akira Takahara Hikaru Tanaka.
    • Journal Title

      Bioimages.

      Volume: 18 Pages: 11-22

    • DOI

      DOI:http://dx.doi.org/10.11169/bioimages.18.11

    • Peer Reviewed
  • [Journal Article] Effects of S(+)-efonidipine on the rabbit sinus node action potential and calcium channel subunits CaV1.2, CaV1.3and CaV 3.1.2010

    • Author(s)
      Hikaru Tanaka, Iyuki Namekata, Toru Ogawa, Yayoi Tsuneoka, Chisa Komikado, Akira Takahara, Naoko Iida-Tanaka, Hiroko Nakaseko, Hiromichi Tsuru, Satomi Adachi-Akahane.
    • Journal Title

      Eur J Pharmacol

      Volume: 649 (1-3) Pages: 263-267

    • DOI

      DOI: 10.1016/j.ejphar.2010.09.014.

    • Peer Reviewed
  • [Presentation] マウス肺静脈心筋自発活動の発生機序に関する薬理学的検討2013

    • Author(s)
      鶴田將人
    • Organizer
      日本薬学会第133 年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2013-03-28
  • [Presentation] モルモット肺静脈心筋の自発活動に対する vidarabine の作用2013

    • Author(s)
      河原圭
    • Organizer
      日本薬学会第133 年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2013-03-28
  • [Presentation] 心筋における局所カルシウムシグナル調節の多様性;次世代の会シンポジウム、Ca2+チャネルマイクロドメインの分子制御基盤とその生理的意義オーガナイザー兼シンポジスト2013

    • Author(s)
      行方衣由紀
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場 (福岡)
    • Year and Date
      2013-03-22
  • [Presentation] マウス肺静脈心筋の電気活動2012

    • Author(s)
      恒岡弥生
    • Organizer
      第29回日本心電学会学術集会
    • Place of Presentation
      幕張メッセ国際会議場 (千葉)
    • Year and Date
      2012-10-12
  • [Presentation] モルモット肺静脈心筋自発活動の交感神経による制御機構2012

    • Author(s)
      白川亮
    • Organizer
      第126回日本薬理学会関東部会
    • Place of Presentation
      北里大学薬学部 (東京)
    • Year and Date
      2012-07-14
  • [Presentation] 肺静脈心筋の電気的自発活動の発生機序:心房細動治療標的としての可能性 特別シンポジウム:次世代創薬に向けた新たなストラテジー オーガナイザー兼シンポジスト2012

    • Author(s)
      行方衣由紀
    • Organizer
      日本薬学会第132 年会
    • Place of Presentation
      北海道大学 (北海道)
    • Year and Date
      2012-03-29
  • [Presentation] モルモット肺静脈心筋の電気的自発活動とカリウム電流2012

    • Author(s)
      恒岡弥生
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2012-03-14
  • [Presentation] Membrane potential and intracellular calcium oscillations in the guinea-pig and rat pulmonary vein myocardium.2011

    • Author(s)
      Iyuki Namekata
    • Organizer
      The 28th Annual Meeting of the International Society for Heart Research Japanese Section.
    • Place of Presentation
      Tokyo(Japan)
    • Year and Date
      2011-12-03
  • [Presentation] モルモット肺静脈心筋自発活動における細胞内 Ca2+動態と電気生理学的性質2011

    • Author(s)
      恒岡弥生
    • Organizer
      第125回日本薬理学会関東部会
    • Place of Presentation
      日本大学薬学部(千葉)
    • Year and Date
      2011-10-15
  • [Presentation] 伸展刺激に起因するモルモット肺静脈心筋の高頻度自発活動について2011

    • Author(s)
      疋田康
    • Organizer
      第55回日本薬学会関東支部大会
    • Place of Presentation
      東邦大学薬学部(千葉)
    • Year and Date
      2011-10-08
  • [Presentation] モルモットおよびラット肺静脈心筋の自発活動における細胞内 Ca2+の役割2011

    • Author(s)
      秋葉明子
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2011
    • Place of Presentation
      北里大学薬学部(東京)
    • Year and Date
      2011-08-31
  • [Presentation] モルモットおよびラット肺静脈心筋の電気的自発活動とカルシウム動態2011

    • Author(s)
      恒岡弥生
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜 (神奈川)
    • Year and Date
      2011-03-24
  • [Presentation] モルモット肺静脈の興奮伝導に対するベプリジルの作用特性2010

    • Author(s)
      高原章
    • Organizer
      第27回日本心電学会学術集会
    • Place of Presentation
      大分全日空ホテル(大分)
    • Year and Date
      2010-10-09
  • [Presentation] モルモット肺静脈心筋の組織・細胞の形態および自発活動2010

    • Author(s)
      恒岡弥生
    • Organizer
      第19回日本バイオイメージング学会学術集会
    • Place of Presentation
      慶應義塾大学日吉キャンパス (神奈川)
    • Year and Date
      2010-09-10
  • [Remarks]

    • URL

      http://www.mnc.toho-u.ac.jp/v-lab/shinkin/index.html

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Published: 2014-08-29  

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