2011 Fiscal Year Final Research Report
Syntheses of PET probes of Chinese medicinal plants, and those pharmacokinetics analysis
Project/Area Number |
22790265
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
General pharmacology
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Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
ISHII Hideki 独立行政法人理化学研究所, 分子イメージング創薬化学研究チーム, 副チームリーダー (80425610)
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Project Period (FY) |
2010 – 2011
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Keywords | 生薬 / 天然物薬理学 / PET |
Research Abstract |
β-Sitosterol, 6-gingerol, curcumin, parthenolide, and evodiamine, which have used for the synthesis of PET-probe precursors or standard samples, have isolated using column chromatography after the extraction with organic solvents of corresponding powders from the commercially available Chinese medicinal plants : Pinellia tuber, Zingiber siccatum, Curcuma longa, Feverfew, and Evodiae fructus. Corresponding^<11> C-PET probe precursors(boronic acid esters) ofβ-sitosterol and curcumin have successfully synthesized.
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Research Products
(7 results)
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[Journal Article] PET Imaging. Based Evaluation of Hepatobiliary Transport in Humans with(15R)-^<11> C-TIC-Me2012
Author(s)
Tadayuki Takashima, Satoshi Kitamura, Yasuhiro Wada, Masaaki Tanaka, Yoshihito Shigihara, Hideki Ishii, Ryosuke Ijuin, Susumu Shiomi, Takahiro Nakae, Yumiko Watanabe, Yilong Cui, Hisashi Doi, Masaaki Suzuki, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyam
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Journal Title
J. Nucl. Med
Volume: 53
Pages: 741-748
Peer Reviewed
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[Presentation] EVALUATION OF IN VIVO HEPATOBILIARY TRANSPORT USING POSITRON EMISSION TOMOGRAPHY(PET): STUDIES IN RATS AND APPLICATION TO MICRODOSING CLINICAL STUDIES2010
Author(s)
Tadayuki Takashima, Hiroko Nagata, Hideki Ishii, Ryosuke Ijuin, Takahiro Nakae, Masaaki Tanaka, Yoshihito Shigihara, Suzuka Ataka, Hisashi Doi, Yasuhiro Wada, Masaaki Suzuki, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama, Yasuyoshi Watanabe
Organizer
9^<th> ISSX international symposioum
Place of Presentation
Istanbul
Year and Date
20100904-08