2011 Fiscal Year Final Research Report
Identification of the mechanisms of pulmonary surfactant phospholipid transport and lamellar body production.
| Project/Area Number |
22790270
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HISHIKAWA Daisuke 東京大学, 大学院・医学系研究科, 特任研究員 (10569966)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 生体分子医学 |
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| Research Abstract |
In this study, I identified the candidate gene "A" for pulmonary surfactant phospholipid transporter. Gene "A" was highly expressed in mouse lung, especially in alveolar type II(ATII) cells, which produce the pulmonary surfactant. Furthermore, the expression of gene "A" was promoted during perinatal periods in mouse lung. The candidate "A" was localized at lamellar bodies in mouse primary ATII cells. The recombinant protein "A" was GTP-dependently bound to the disaturated phosphatidylcholine, which is the major component of pulmonary surfactant phospholipid.
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