2011 Fiscal Year Final Research Report
Investigation of the signal network regulating adult liver progenitor cells(oval cells) involved in liver regeneration
| Project/Area Number |
22790271
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ITOH Tohru 東京大学, 分子細胞生物学研究所, 助教 (50396917)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 再生医学 / シグナル伝達 / 肝臓 / 組織幹細胞 |
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| Research Abstract |
In severely damaged livers where hepatocyte proliferation is impaired, facultative liver stem/progenitor cells(oval cells) proliferate and are assumed to contribute to regeneration. We sought to elucidate the underlying mechanisms by focusing on cell-to-cell interaction that may take place in the course of oval cell activation, and have identified a novel cell population that provides a critical intercellular signaling molecule, thereby supporting and regulating oval cells.
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