2012 Fiscal Year Final Research Report
The role of cell proliferation in cellular reprogramming
Project/Area Number |
22790283
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
General medical chemistry
|
Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2010 – 2012
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Keywords | iPS細胞 / リプログラミング |
Research Abstract |
Transcription factor-induced reprogramming requires relative longer time compared to those by nuclear transfer and cell fusion. Since cells actively proliferate during this period, we can imagine its importance in reprogramming process. However, the role of cell proliferation was unclear. In this study, we demonstrated that cell proliferation is dispensable for the initiation of reprogramming but essential for the maturation.
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Research Products
(13 results)