2011 Fiscal Year Final Research Report
Cell therapy for Muscular Dystrophy using myogenic progenitor cells derived from human iPS cells
| Project/Area Number |
22790284
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | iPS細胞 / 筋ジストロフィー / 再生医療 / 骨格筋前駆細胞 |
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| Research Abstract |
We developed an efficient and simple method to generate integration-free human iPSCs with episomal plasmid vectors from multiple donors, including two in which only one HLA haplotype was detected. These iPSCs were effectively differentiated into various cell types in vivo and in vitro. The two putatively HLA-homozygous iPSC lines match~ 20% of the Japanese population at major HLA loci.
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