2011 Fiscal Year Final Research Report
Analyses of intercellular signaling during generation of induced pluripotent stem cell from somatic cells
| Project/Area Number |
22790286
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
AOI Takashi 京都大学, iPS細胞研究所, 教授 (00546997)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 人工多能性幹細胞 / 細胞間シグナリング / NF-_kB |
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| Research Abstract |
Microarray analysis showed the expression level of many genes involved in intercellular signaling changed during generation of induced pluripotent stem(iPS) cells from somatic cells. The genes included diverse downstream targets of NF-kB signal. To address the function of NF-kB signaling during iPS cell generation process, we conducted loss-of-function experiment and demonstrated that NF-kB signaling have positive effect on the reprogramming process, but not maintenance of established iPS cells.
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