CNS regeneration by regulating axonal transport

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790289
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Kansai University of Health Sciences
• Principal Investigator: HATA Katsuhiko 関西医療大学, 保健医療学部, 研究員 (60506228)
• Project Period (FY): 2010 – 2011
• Keywords: 再生医学

Research Abstract

We observed the phenomenon of axotomy-induced axonogenesis in rat embryonic hippocampal neurons in vitro and showed the involvement of retrograde transport by dynein-dynactin complex in this phenomenon. Moreover, Importin ss was locally translated after axotomy followed by the interaction with the dynein-importin α complex. These findings suggest that local translation and retrograde transport system in injured axons play an important roles in the axotomy-induced axonogenesis of embryonic hippocampal neurons.

Research Products

• [Journal Article] Axotomy induces axonogenesis in hippocampal neurons through STAT3 (2011)
  • Author(s): Ohara, R., Fujita, Y., Hata, K., Nakagawa, M. and Yamashita, T.
  • Journal Title: Cell Death Dis Volume: 2 Pages: e175
• [Journal Article] Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on Importin ss (2011)
  • Author(s): Ohara, R., Hata, K., Yasuhara, N., Mehmood, R., Yoneda, Y., Nakagawa, M. and Yamashita, T.
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 405 Pages: 697-702